DMeOBNegative allosteric modulator at mGlu5 CAS# 40252-74-2 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 40252-74-2 | SDF | Download SDF |
| PubChem ID | 9604993 | Appearance | Powder |
| Formula | C16H16N2O2 | M.Wt | 268.31 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO | ||
| Chemical Name | N'-(3-methoxyphenyl)-N-[(3-methoxyphenyl)methylidene]methanimidamide | ||
| SMILES | COC1=CC=CC(=C1)C=NC=NC2=CC(=CC=C2)OC | ||
| Standard InChIKey | CWHVUMNEZIBZFC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H16N2O2/c1-19-15-7-3-5-13(9-15)11-17-12-18-14-6-4-8-16(10-14)20-2/h3-12H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Negative allosteric modulator of the metabotropic glutamate receptor mGlu5; displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM). |
DMeOB Dilution Calculator
DMeOB Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.727 mL | 18.6352 mL | 37.2703 mL | 74.5406 mL | 93.1758 mL |
| 5 mM | 0.7454 mL | 3.727 mL | 7.4541 mL | 14.9081 mL | 18.6352 mL |
| 10 mM | 0.3727 mL | 1.8635 mL | 3.727 mL | 7.4541 mL | 9.3176 mL |
| 50 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.4908 mL | 1.8635 mL |
| 100 mM | 0.0373 mL | 0.1864 mL | 0.3727 mL | 0.7454 mL | 0.9318 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.[Pubmed:12920211]
Mol Pharmacol. 2003 Sep;64(3):731-40.
We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of effects, ranging from positive to negative allosteric modulation, and includes compounds that do not themselves modulate mGluR5 agonist activity but rather prevent other family members from exerting their modulatory effects. 3,3'-Difluorobenzaldazine (DFB) has no agonist activity, but it acts as a selective positive allosteric modulator of human and rat mGluR5. DFB potentiates threshold responses to glutamate, quisqualate, and 3,5-dihydroxyphenylglycine in fluorometric Ca2+ assays 3- to 6-fold, with EC50 values in the 2 to 5 microM range, and at 10 to 100 microM, it shifts mGluR5 agonist concentration-response curves approximately 2-fold to the left. The analog 3,3'-dimethoxybenzaldazine (DMeOB) acts as a negative modulator of mGluR5 agonist activity, with an IC50 of 3 microM in fluorometric Ca2+ assays, whereas the analog 3,3'-dichlorobenzaldazine (DCB) does not exert any apparent modulatory effect on mGluR5 activity. However, DCB seems to act as an allosteric ligand with neutral cooperativity, preventing the positive allosteric modulation of mGluRs by DFB as well as the negative modulatory effect of DMeOB. None of these analogs affects binding of [3H]quisqualate to the orthosteric (glutamate) site, but they do inhibit [3H]3-methoxy-5-(2-pyridinylethynyl)pyridine binding to the site for 2-methyl-6-(phenylethynyl)-pyridine, a previously identified negative allosteric modulator. With the use of these compounds, we provide evidence that allosteric sites on GPCRs can respond to closely related ligands with a range of pharmacological activities from positive to negative modulation as well as to neutral competition of this modulation.
