Conduritol A

CAS# 526-87-4

Conduritol A

Catalog No. BCN5683----Order now to get a substantial discount!

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Chemical structure

Conduritol A

3D structure

Chemical Properties of Conduritol A

Cas No. 526-87-4 SDF Download SDF
PubChem ID 136345 Appearance Cryst.
Formula C6H10O4 M.Wt 146.1
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name cyclohex-5-ene-1,2,3,4-tetrol
SMILES C1=CC(C(C(C1O)O)O)O
Standard InChIKey LRUBQXAKGXQBHA-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H10O4/c7-3-1-2-4(8)6(10)5(3)9/h1-10H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Conduritol A

The barks of Marsdenia condurango

Biological Activity of Conduritol A

DescriptionConduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting cataracts through the inhibition of lens aldose reductase.
TargetsTNF-α | Lens aldose reductase
In vivo

Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre[Pubmed: 19294862]

Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.

To investigates the mechanism of hypooglycemic effect of Conduritol A of stems of Gymnema sylvestre.
METHODS AND RESULTS:
Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index. Compared with diabetic model mice, high and middosage of Conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of Conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of Conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each Conduritol A group were more than those in the model group.
CONCLUSIONS:
Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.

Protocol of Conduritol A

Animal Research

Effect of Conduritol A, a Polyol from Gymnema sylvestre, on the Development of Diabetic Cataracts in Streptozotocin-treated Rats and on Aldose Reductase.[Reference: WebLink]

Biosci.Biotech. Biochem.,1994, 58(4):756-7.


METHODS AND RESULTS:
Streptozotocin-diabetic rats were maintained on a stock diet for 16 weeks and some were given Conduritol A (10 mg/kg/day). The administration of Conduritol A, having a hypoglycemic effect, markedly prevented the diabetic rats from getting cataracts. In practice, Conduritol A inhibited aldose reductase (EC 1.1.1.21) that is capable of catalyzing the conversion of aldoses to sugar alcohols in the polyol pathway. In an in vitro assay, lens aldose reductase was most effectively inhibited by Conduritol A when α,β-d-glucose was used as a substrate. Some enzymes from the rats were not inhibited by Conduritol A. Neither an intraperitoneal injection nor oral dosage of Conduritol A caused acute toxicity in the rats.
CONCLUSIONS:
These findings suggest that the inhibition of lens aldose reductase by Conduritol A may be responsible for its cataract-suppressing effect.

Conduritol A Dilution Calculator

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Conduritol A Molarity Calculator

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Preparing Stock Solutions of Conduritol A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.8446 mL 34.2231 mL 68.4463 mL 136.8925 mL 171.1157 mL
5 mM 1.3689 mL 6.8446 mL 13.6893 mL 27.3785 mL 34.2231 mL
10 mM 0.6845 mL 3.4223 mL 6.8446 mL 13.6893 mL 17.1116 mL
50 mM 0.1369 mL 0.6845 mL 1.3689 mL 2.7379 mL 3.4223 mL
100 mM 0.0684 mL 0.3422 mL 0.6845 mL 1.3689 mL 1.7112 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Conduritol A

[Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre].[Pubmed:19294862]

Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.

OBJECTIVE: To investigates the mechanism of hypooglycemic effect of Conduritol A of stems of Gymnema sylvestre. METHOD: Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index. RESULT: Compared with diabetic model mice, high and middosage of Conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of Conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of Conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each Conduritol A group were more than those in the model group. CONCLUSION: Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.

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