Collagen proline hydroxylase inhibitorCollagen proline hydroxylase inhibitor CAS# 223666-07-7 |
Related Products
- Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
Catalog No.:BCC4600
CAS No.:168555-66-6
- Eribulin
Catalog No.:BCC5174
CAS No.:253128-41-5
- Eribulin mesylate
Catalog No.:BCC5173
CAS No.:441045-17-6
- CYT997 (Lexibulin)
Catalog No.:BCC4601
CAS No.:917111-44-5
- MPC 6827 hydrochloride
Catalog No.:BCC8040
CAS No.:917369-31-4
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 223666-07-7 | SDF | Download SDF |
| PubChem ID | 9928521 | Appearance | Powder |
| Formula | C18H18N4O4 | M.Wt | 354.36 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 13.15 mg/mL (37.11 mM; Need ultrasonic and warming) | ||
| Chemical Name | N-ethyl-8-nitro-7-oxo-N-propyl-10H-1,10-phenanthroline-3-carboxamide | ||
| SMILES | CCCN(CC)C(=O)C1=CN=C2C(=C1)C=CC3=C2NC=C(C3=O)[N+](=O)[O-] | ||
| Standard InChIKey | XUARBCHSPWMKRC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H18N4O4/c1-3-7-21(4-2)18(24)12-8-11-5-6-13-16(15(11)19-9-12)20-10-14(17(13)23)22(25)26/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,23) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents. |
Collagen proline hydroxylase inhibitor Dilution Calculator
Collagen proline hydroxylase inhibitor Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.822 mL | 14.1099 mL | 28.2199 mL | 56.4398 mL | 70.5497 mL |
| 5 mM | 0.5644 mL | 2.822 mL | 5.644 mL | 11.288 mL | 14.1099 mL |
| 10 mM | 0.2822 mL | 1.411 mL | 2.822 mL | 5.644 mL | 7.055 mL |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.1288 mL | 1.411 mL |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.5644 mL | 0.7055 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
IC50: N/A
Collagen proline hydroxylase inhibitor is one member of the collagen proline hydroxylase inhibitor family, which are used as antifibroproliferative agents. Proline hydroxylase is a multiple function oxygenase catalyzing specific prolyl residues in the collagen peptide precursor. Proline hydroxylase has been known as one of the critical enzymes in the biosynthesis of collagen and its activity is enhanced in tissues of various pathological fibrosis. Thus, the specific inhibitor of proline hydroxylase could have clinical application in fibrotic diseases treatment.
In vitro: One of collagen proline hydroxylase inhibitors, P-1894B, was found to in vitro inhibit proline hydroxylase and had been proposed as a topical treatment for dermal fibrosis. P-1894B was observed to be with similar activities on one fibroblast line from a patient with infection and two fibroblast lines from normal human skin. 72-hour drug exposure on growing cells showed both time- and dose-dependent inhibition of proliferation. A similar result was also observed in the epithelial cell line NCTC 2544 [1].
In vivo: So far, collagen proline hydroxylase inhibitor has not been applied to animal in vivo study.
Clinical trial: Currently, no clinical study is available.
Reference:
[1] Priestley GC. Toxicity of the anthraquinone glycoside P-1894B for human skin fibroblasts. Br J Dermatol.1987 Jul;117(1):67-72.
Featured Products
- Collagen proline hydroxylase inhibitor-1
Catalog No.:BCC1495
CAS No.:223663-32-9
- K-115 free base
Catalog No.:BCC5501
CAS No.:223645-67-8
- Tiadinil
Catalog No.:BCC8070
CAS No.:223580-51-6
- CPA inhibitor
Catalog No.:BCC1500
CAS No.:223532-02-3
- YM 58483
Catalog No.:BCC7817
CAS No.:223499-30-7
- ONO 4817
Catalog No.:BCC2375
CAS No.:223472-31-9
- GLP-2 (human)
Catalog No.:BCC5891
CAS No.:223460-79-5
- FG2216
Catalog No.:BCC6402
CAS No.:223387-75-5
- Polygalacic acid
Catalog No.:BCN5898
CAS No.:22338-71-2
- Grandifloric acid
Catalog No.:BCN4669
CAS No.:22338-69-8
- Grandiflorenic acid
Catalog No.:BCN4670
CAS No.:22338-67-6
- 9-Hydroxy-alpha-lapachone
Catalog No.:BCN5060
CAS No.:22333-58-0
New Products
- Mirabegron (YM178)
Catalog No.:BCC3814
CAS No.:223673-61-8
- Eupatilin
Catalog No.:BCN2336
CAS No.:22368-21-4
- 4-Methoxysalicylic acid
Catalog No.:BCN7783
CAS No.:2237-36-7
- Sodium Monensin
Catalog No.:BCC5319
CAS No.:22373-78-0
- NPE-caged-HPTS
Catalog No.:BCC5950
CAS No.:223759-19-1
- Bestatin trifluoroacetate
Catalog No.:BCC3909
CAS No.:223763-80-2
- Pedalitin
Catalog No.:BCN3954
CAS No.:22384-63-0
- Serratenediol
Catalog No.:BCN5061
CAS No.:2239-24-9
- 3,8-Di-O-methylellagic acid
Catalog No.:BCN5062
CAS No.:2239-88-5
- Aristola-1(10),8-dien-2-one
Catalog No.:BCN7608
CAS No.:22391-34-0
- Cyclobuxine D
Catalog No.:BCC9221
CAS No.:2241-90-9
- 3-Epiturraeanthin
Catalog No.:BCN5063
CAS No.:22415-24-3
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents.
Collagen proline hydroxylase inhibitor,223666-07-7,Natural Products,Collagen proline hydroxylase, buy Collagen proline hydroxylase inhibitor , Collagen proline hydroxylase inhibitor supplier , purchase Collagen proline hydroxylase inhibitor , Collagen proline hydroxylase inhibitor cost , Collagen proline hydroxylase inhibitor manufacturer , order Collagen proline hydroxylase inhibitor , high purity Collagen proline hydroxylase inhibitor
