CnidilinCAS# 14348-22-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 14348-22-2 | SDF | Download SDF |
| PubChem ID | 821449 | Appearance | Powder |
| Formula | C17H16O5 | M.Wt | 300.31 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-methoxy-4-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one | ||
| SMILES | CC(=CCOC1=C2C=COC2=C(C3=C1C=CC(=O)O3)OC)C | ||
| Standard InChIKey | NNDOCYLWULORAM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H16O5/c1-10(2)6-8-20-14-11-4-5-13(18)22-16(11)17(19-3)15-12(14)7-9-21-15/h4-7,9H,8H2,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous system diseases. |
| Targets | P-gp |
| In vitro | In vitro permeability analysis, pharmacokinetic and brain distribution study in mice of imperatorin, isoimperatorin and cnidilin in Radix Angelicae Dahuricae.[Pubmed: 23353658]Fitoterapia. 2013 Mar;85:144-53.Coumarins are important constituents of Radix Angelicae Dahuricae, a well-known traditional Chinese medicine possess several known bioactivities with potentials in the treatment of central nervous system diseases. |
Cnidilin Dilution Calculator
Cnidilin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3299 mL | 16.6495 mL | 33.2989 mL | 66.5978 mL | 83.2473 mL |
| 5 mM | 0.666 mL | 3.3299 mL | 6.6598 mL | 13.3196 mL | 16.6495 mL |
| 10 mM | 0.333 mL | 1.6649 mL | 3.3299 mL | 6.6598 mL | 8.3247 mL |
| 50 mM | 0.0666 mL | 0.333 mL | 0.666 mL | 1.332 mL | 1.6649 mL |
| 100 mM | 0.0333 mL | 0.1665 mL | 0.333 mL | 0.666 mL | 0.8325 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Poriol
Catalog No.:BCN6816
CAS No.:14348-16-4
- (Arg)9 peptide
Catalog No.:BCC5336
CAS No.:143413-47-2
- SAR131675
Catalog No.:BCC5097
CAS No.:1433953-83-3
- Naratriptan
Catalog No.:BCC5053
CAS No.:143388-64-1
- Bryostatin 3
Catalog No.:BCC5620
CAS No.:143370-84-7
- SMIP004
Catalog No.:BCC1955
CAS No.:143360-00-3
- RS 56812 hydrochloride
Catalog No.:BCC6877
CAS No.:143339-12-2
- UNC 2400
Catalog No.:BCC5625
CAS No.:1433200-49-7
- Ac-YVAD-CHO
Catalog No.:BCC4021
CAS No.:143313-51-3
- H-Chg-OH
Catalog No.:BCC3162
CAS No.:14328-51-9
- RA-XI
Catalog No.:BCN3514
CAS No.:143277-27-4
- AGI-6780
Catalog No.:BCC1331
CAS No.:1432660-47-3
- 5,8-Dihydroxypsoralen
Catalog No.:BCC8104
CAS No.:14348-23-3
- LOE 908 hydrochloride
Catalog No.:BCC7327
CAS No.:143482-60-4
- Emtricitabine
Catalog No.:BCC3774
CAS No.:143491-57-0
- Dammarenediol II
Catalog No.:BCN6240
CAS No.:14351-29-2
- 3-Acetoxy-24-hydroxydammara-20,25-diene
Catalog No.:BCN1569
CAS No.:143519-04-4
- (4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
Catalog No.:BCN8364
CAS No.:143527-70-2
- Shancigusin I
Catalog No.:BCN8272
CAS No.:1435488-35-9
- XMD17-109
Catalog No.:BCC2061
CAS No.:1435488-37-1
- L 012 sodium salt
Catalog No.:BCC6362
CAS No.:143556-24-5
- Rocuronium
Catalog No.:BCC1906
CAS No.:143558-00-3
- Virgatic acid
Catalog No.:BCN6744
CAS No.:14356-51-5
- Diprenorphine
Catalog No.:BCC5954
CAS No.:14357-78-9
In vitro permeability analysis, pharmacokinetic and brain distribution study in mice of imperatorin, isoimperatorin and cnidilin in Radix Angelicae Dahuricae.[Pubmed:23353658]
Fitoterapia. 2013 Mar;85:144-53.
Coumarins are important constituents of Radix Angelicae Dahuricae, a well-known traditional Chinese medicine possess several known bioactivities with potentials in the treatment of central nervous system diseases. By using an HPLC-MS/MS method, we analyzed the in vivo plasma and brain pharmacokinetics of three ingredients of coumarins, including imperatorin, isoimperatorin and Cnidilin in mice after oral administration of Dahuricae extract at doses of 800mg/kg. The biosamples were prepared using acetonitrile precipitation and the separation was achieved on an XDB-C18 column by gradient elution. The BBB permeability and P-gp-mediated efflux were further examined in Madin Canine kidney cells transfected with full length cDNA for human multidrug resistance gene1 (MDCKII-MDR1). Our results demonstrate that the method has excellent and satisfactory selectivity, sensitivity, linearity, precision, and accuracy for simultaneous determination of imperatorin, isoimperatorin and Cnidilin. The pharmacokinetics parameters were determined by using noncompartmental analyses, including the AUC(0-t) in plasma (1695.22, 1326.45 and 636.98mg*h/L), the AUC(0-t) in brain (1812.35, 2125.17 and 1145.83ng*h/g) as well as the T1/2 in plasma (0.66, 0.82, 0.97h) and brain (0.96, 1.1, 0.99h) for imperatorin, isoimperatorin and Cnidilin, respectively, suggesting that the three coumarins could easily pass through the BBB in vivo. In the in vitro model we observed high permeability of imperatorin and isoimperatorin with the P-gp-mediated efflux ratios of 0.53 and 0.06, as well as medium permeability of Cnidilin with 0.82. All data suggest that these three coumarins have high BBB permeability and have pharmacokinetic potentials for the treatment of central nervous system diseases.
