Cl-HIBOCAS# 909400-43-7 |
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Chemical structure
3D structure
| Cas No. | 909400-43-7 | SDF | Download SDF |
| PubChem ID | 4694356 | Appearance | Powder |
| Formula | C6H7ClN2O4 | M.Wt | 206.59 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | 4-Chlorohomoibotenic acid | ||
| Solubility | Soluble to 20 mM in water | ||
| Chemical Name | 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid | ||
| SMILES | C(C1=C(C(=O)NO1)Cl)C(C(=O)O)N | ||
| Standard InChIKey | FDSXCQTXUSQQFH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C6H7ClN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively). |
Cl-HIBO Dilution Calculator
Cl-HIBO Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.8405 mL | 24.2025 mL | 48.4051 mL | 96.8101 mL | 121.0126 mL |
| 5 mM | 0.9681 mL | 4.8405 mL | 9.681 mL | 19.362 mL | 24.2025 mL |
| 10 mM | 0.4841 mL | 2.4203 mL | 4.8405 mL | 9.681 mL | 12.1013 mL |
| 50 mM | 0.0968 mL | 0.4841 mL | 0.9681 mL | 1.9362 mL | 2.4203 mL |
| 100 mM | 0.0484 mL | 0.242 mL | 0.4841 mL | 0.9681 mL | 1.2101 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).[Pubmed:12747796]
J Med Chem. 2003 May 22;46(11):2246-9.
On the basis of structural studies, chloro-homoibotenic acid (Cl-HIBO) was designed and synthesized. Cl-HIBO was characterized in binding and electrophysiology experiments on native and cloned subtypes of GluRs. Electrophysiological selectivities ranged from 275 to 1600 for GluR1/2 over GluR3/4. The potent AMPA receptor activity was strongly desensitizing and the neurotoxicity similar to AMPA. Thus, Cl-HIBO is the most subtype selective agonist reported to date on GluR1/2, and offers a new standard for selectively studying subtypes of AMPA receptors.
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