4-Hydroxy-2,3-dimethoxyxanthoneCAS# 10527-38-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 10527-38-5 | SDF | Download SDF |
| PubChem ID | 378690 | Appearance | Yellow powder |
| Formula | C15H12O5 | M.Wt | 272.25 |
| Type of Compound | Xanthones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-hydroxy-2,3-dimethoxyxanthen-9-one | ||
| SMILES | COC1=C(C(=C2C(=C1)C(=O)C3=CC=CC=C3O2)O)OC | ||
| Standard InChIKey | HWDHDJJDOUMUHF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H12O5/c1-18-11-7-9-12(16)8-5-3-4-6-10(8)20-14(9)13(17)15(11)19-2/h3-7,17H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
4-Hydroxy-2,3-dimethoxyxanthone Dilution Calculator
4-Hydroxy-2,3-dimethoxyxanthone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6731 mL | 18.3655 mL | 36.7309 mL | 73.4619 mL | 91.8274 mL |
| 5 mM | 0.7346 mL | 3.6731 mL | 7.3462 mL | 14.6924 mL | 18.3655 mL |
| 10 mM | 0.3673 mL | 1.8365 mL | 3.6731 mL | 7.3462 mL | 9.1827 mL |
| 50 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.4692 mL | 1.8365 mL |
| 100 mM | 0.0367 mL | 0.1837 mL | 0.3673 mL | 0.7346 mL | 0.9183 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis.[Pubmed:26900954]
J Nat Prod. 2016 Mar 25;79(3):470-6.
Bioactivity-guided fractionation of the EtOH extract of the branches of Kielmeyera variabilis led to the isolation of a new acylphoroglucinol (1), which was active against all the MRSA strains tested herein, with pronounced activity against strain EMRSA-16. Compound 1 displayed an MIC of 0.5 mg/L as compared with an MIC of 128 mg/L for the control antibiotic norfloxacin. The structure of the new compound was elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry, and experimental and calculated ECD were used to determine the absolute configurations. The compounds beta-sitosterol (2), stigmasterol (3), ergost-5-en-3-ol (4), and osajaxanthone (5) also occurred in the n-hexane fraction. The EtOAc fraction contained nine known xanthones: 3,6-dihydroxy-1,4,8-trimethoxyxanthone (6), 3,5-dihydroxy-4-methoxyxanthone (7), 3,4-dihydroxy-6,8-dimethoxyxanthone (8), 3,4-dihydroxy-2-methoxyxanthone (9), 5-hydroxy-1,3-dimethoxyxanthone (10), 4-Hydroxy-2,3-dimethoxyxanthone (11), kielcorin (12), 3-hydroxy-2-methoxyxanthone (13), and 2-hydroxy-1-methoxyxanthone (14), which showed moderate to low activity against the tested MRSA strains.
Anti-inflammatory xanthones from the twigs of Hypericum oblongifolium wall.[Pubmed:21870324]
Planta Med. 2011 Dec;77(18):2013-8.
Two new xanthonolignoids, hypericorin A (1) and hypericorin B (2), along with five known new source compounds, a xanthonolignoid, kielcorin (3), 4-Hydroxy-2,3-dimethoxyxanthone (4), 3,4,5-trihydroxyxanthone (5), 1,3-dihydroxy-5-methoxyxanthone ( 6) and 1,3,7-trihydroxyxanthone (7), were isolated from the stems (twigs) of Hypericum oblongifolium Wall. The structures of the new compounds were deduced on the basis of spectroscopic techniques (EI-MS, HREI-MS, (1)H NMR, (13)C NMR, HMQC, HMBC, and NOESY). We also report herein for the first time the single crystal X-ray structure of compound 6. Compounds 1- 7 were screened for their IN VITRO anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils; compounds 1, 2, 3, 5, and 7 showed significant activities (IC (50) = 816.23 +/- 73.30, 985.20 +/- 55.80, 965.21 +/- 65.80, 907.20 +/- 50.80, 975.20 +/- 81.10 microM, respectively), compound 6 showed moderate activity (IC (50) = 2500.85 +/- 50.50 microM), while compound 4 was totally inactive at 1000 microg/mL as compared to the positive control used, indomethacin (IC (50) = 757.99 +/- 5.90 microM), and aspirin (IC (50) = 279.44 +/- 4.40 microM). Compound 4 was also inactive in comparison with other tested Hypericum compounds.
