24,25-Dihydroxycycloartan-3-oneCAS# 155060-48-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 155060-48-3 | SDF | Download SDF |
| PubChem ID | 101929808 | Appearance | Powder |
| Formula | C30H50O3 | M.Wt | 458.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1S,3R,8R,11S,12S,15R,16R)-15-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecan-6-one | ||
| SMILES | CC(CCC(C(C)(C)O)O)C1CCC2(C1(CCC34C2CCC5C3(C4)CCC(=O)C5(C)C)C)C | ||
| Standard InChIKey | JCGYBQRUVSZLCH-FDIVVELCSA-N | ||
| Standard InChI | InChI=1S/C30H50O3/c1-19(8-11-24(32)26(4,5)33)20-12-14-28(7)22-10-9-21-25(2,3)23(31)13-15-29(21)18-30(22,29)17-16-27(20,28)6/h19-22,24,32-33H,8-18H2,1-7H3/t19-,20-,21+,22+,24-,27-,28+,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. (24xi)-24,25-Dihydroxycycloartan-3-one exhibits inhibitory effects on both EBV-EA and NOR 1 activation. |
24,25-Dihydroxycycloartan-3-one Dilution Calculator
24,25-Dihydroxycycloartan-3-one Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1801 mL | 10.9004 mL | 21.8007 mL | 43.6015 mL | 54.5019 mL |
| 5 mM | 0.436 mL | 2.1801 mL | 4.3601 mL | 8.7203 mL | 10.9004 mL |
| 10 mM | 0.218 mL | 1.09 mL | 2.1801 mL | 4.3601 mL | 5.4502 mL |
| 50 mM | 0.0436 mL | 0.218 mL | 0.436 mL | 0.872 mL | 1.09 mL |
| 100 mM | 0.0218 mL | 0.109 mL | 0.218 mL | 0.436 mL | 0.545 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- SM-21 maleate
Catalog No.:BCC6780
CAS No.:155059-42-0
- N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide
Catalog No.:BCC6784
CAS No.:155054-42-5
- 4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid
Catalog No.:BCN1554
CAS No.:155051-85-7
- Usaramine
Catalog No.:BCN2121
CAS No.:15503-87-4
- Isatidine
Catalog No.:BCN2120
CAS No.:15503-86-3
- Pancuronium dibromide
Catalog No.:BCC4578
CAS No.:15500-66-0
- Ac-Arg-OH.2H2O
Catalog No.:BCC2855
CAS No.:155-84-0
- Rhaponiticin
Catalog No.:BCN5392
CAS No.:155-58-8
- Methscopolamine
Catalog No.:BCC4577
CAS No.:155-41-9
- RU 58841
Catalog No.:BCC1911
CAS No.:154992-24-2
- Erysenegalensein E
Catalog No.:BCN3979
CAS No.:154992-17-3
- BAY-u 9773
Catalog No.:BCC7576
CAS No.:154978-38-8
- 11-Deoxyalisol B
Catalog No.:BCN3359
CAS No.:155073-73-7
- 6-ethyl-3-methyl-4-oxo-4H-pyran-2-carboxylic acid
Catalog No.:BCC8270
CAS No.:1551-49-1
- 2-[1-(4-Piperonyl)piperazinyl]benzothiazole
Catalog No.:BCC6771
CAS No.:155106-73-3
- Rosiglitazone maleate
Catalog No.:BCC2262
CAS No.:155141-29-0
- Plerixafor 8HCl (AMD3100 8HCl)
Catalog No.:BCC4447
CAS No.:155148-31-5
- Plerixafor octahydrobromide
Catalog No.:BCC9123
CAS No.:155148-32-6
- Physapruin A
Catalog No.:BCN7576
CAS No.:155178-03-3
- Cordifolioside A
Catalog No.:BCN8224
CAS No.:155179-20-7
- Cinnamylideneacetic acid
Catalog No.:BCN7777
CAS No.:1552-94-9
- 4-(Dimethylamino)cinnamic acid
Catalog No.:BCN5031
CAS No.:1552-96-1
- 7alpha,15-Dihydroxydehydroabietic acid
Catalog No.:BCN7672
CAS No.:155205-64-4
- Methyl 7,15-dihydroxydehydroabietate
Catalog No.:BCN1693
CAS No.:155205-65-5
Biotransformation of cycloartane-type triterpenes by the fungus Glomerella fusarioides.[Pubmed:16643035]
J Nat Prod. 2006 Apr;69(4):604-7.
Biotransformation of three cycloartane-type triterpenes, cycloartenol (1), 24-methylenecycloartanol (2), and cycloartenone (3), by the fungus Glomerella fusarioides was studied. Compound 1 was converted to 3, cycloart-25-ene-3beta,24-diol (4), and cycloartane-3beta,24,25-triol (5). Compound 2 was metabolized to cycloeucalenol (6) and two new compounds, 24-methylcycloartane-3beta,24,24(1)-triol (7) and 24(1)-methoxy-24-methylcycloartane-3beta,24-diol (8). Compound 3 was converted into two new metabolites, 4alpha,4beta,14alpha-trimethyl-9beta,19-cyclopregnane-3,20-dione (9) and 25-hydroxy-24-methoxycycloartan-3-one (14), and four known compounds, viz., cycloartane-3,24-dione (10), 24-hydroxycycloart-25-en-3-one (11), (23E)-25-hydroxycycloart-23-en-3-one (12), and 24,25-Dihydroxycycloartan-3-one (13). The structures of four new metabolites, 7, 8, 9, and 14, were established by spectroscopic methods.
Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models.[Pubmed:17503850]
J Nat Prod. 2007 Jun;70(6):918-22.
Forty-eight natural and semisynthetic cycloartane-type and related triterpenoids have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells as a primary screening test for anti-tumor promoters. In addition, these triterpenoids have been tested for their inhibitory effects on activation of (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for anti-tumor initiators. All of the compounds tested exhibited inhibitory effects on both EBV-EA and NOR 1 activation. Six of these compounds having a C-24 hydroxylated side chain, viz., (24R)-cycloart-25-ene-3beta,24-diol (9), (24R)-cycloartane-3beta,24,25-triol (11), (24S)-cycloartane-3beta,24,25-triol (12), (24xi)-24-methylcycloartane-3beta,24,241-triol (14), (24xi)-241-methoxy-24-methylcycloartane-3beta,24-diol (15), and (24xi)-24,25-Dihydroxycycloartan-3-one (27), showed higher inhibitory effects than the others tested on both EBV-EA (IC50 values of 6.1-7.4 nM) and NOR 1 activation. Furthermore, compounds 14 and 15 exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
