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12-Oxocalanolide A

12-Oxocalanolide A

Catalog No. BCN4699
Size Price Stock
20mg $298 In stock
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Quality Control of 12-Oxocalanolide A

Chemical structure

12-Oxocalanolide A

Biological Activity of 12-Oxocalanolide A

1. 12-Oxocalanolide A is an inhibitor of HIV-1 reverse transcriptase (RT) and exhibits activity against a variety of viruse selected for resistance to other HIV-1 nonnucleoside RT inhibitors.

12-Oxocalanolide A Dilution Calculator

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12-Oxocalanolide A Molarity Calculator



Chemical Properties of 12-Oxocalanolide A

Cas No. 161753-49-7 SDF Download SDF
SMILES CCCC1=CC(=O)Oc2c3C(=O)[C@H](C)[C@@H](C)Oc3c4C=CC(C)(C)Oc4c12
Standard InChI InChI=1S/C22H24O5/c1-6-7-13-10-15(23)26-21-16(13)20-14(8-9-22(4,5)27-20)19-17(21)18(24)11(2)12(3)25-19/h8-12H,6-7H2,1-5H3/t11-,12-/m1/s1
Type of Compound Coumarins Appearance Yellow powder
Formula C22H24O5 M.Wt 368.43
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 12-Oxocalanolide A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7142 mL 13.5711 mL 27.1422 mL 54.2844 mL 67.8555 mL
5 mM 0.5428 mL 2.7142 mL 5.4284 mL 10.8569 mL 13.5711 mL
10 mM 0.2714 mL 1.3571 mL 2.7142 mL 5.4284 mL 6.7855 mL
50 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.0857 mL 1.3571 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5428 mL 0.6786 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 12-Oxocalanolide A

This product is isolated and purified from the herbs of Calophyllum polyanthum

References on 12-Oxocalanolide A

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.[Pubmed: 9873509]

The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-Oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.


12-Oxocalanolide A ,161753-49-7,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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