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11Beta-hydroxyprogesterone

11Beta-hydroxyprogesterone

Catalog No. BCN2211
Size Price Stock
20mg $70 In stock
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Quality Control of 11Beta-hydroxyprogesterone

Chemical structure

11Beta-hydroxyprogesterone

Biological Activity of 11Beta-hydroxyprogesterone

1. The agonist activity of 11Beta-hydroxyprogesterone is caused by contacts between its 11 beta-hydroxyl group and Asn770, furthermore,1Beta-hydroxyprogesterone is unable to activate the mutant hMR/N770A, in which Ala is substituted for Asn at position 770.

11Beta-hydroxyprogesterone Dilution Calculator

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11Beta-hydroxyprogesterone Molarity Calculator

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Chemical Properties of 11Beta-hydroxyprogesterone

Cas No. 600-57-7 SDF Download SDF
Chemical Name (8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C
Standard InChIKey BFZHCUBIASXHPK-ATWVFEABSA-N
Standard InChI InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1
Type of Compound Steroids Appearance White powder
Formula C21H30O3 M.Wt 330.46
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 11Beta-hydroxyprogesterone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0261 mL 15.1304 mL 30.2608 mL 60.5217 mL 75.6521 mL
5 mM 0.6052 mL 3.0261 mL 6.0522 mL 12.1043 mL 15.1304 mL
10 mM 0.3026 mL 1.513 mL 3.0261 mL 6.0522 mL 7.5652 mL
50 mM 0.0605 mL 0.3026 mL 0.6052 mL 1.2104 mL 1.513 mL
100 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.6052 mL 0.7565 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on 11Beta-hydroxyprogesterone

11Beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.[Pubmed: 12435797]


In contrast, 11Beta-hydroxyprogesterone (11OHP) activated the transiently expressed hMR in COS-7 cells in a dose-dependent manner (ED(50): 10(-8) M) and, like aldosterone, stimulated Ams I(sc) in mpkCCD(cl4) cells. Docking 11Beta-hydroxyprogesterone within the hMR-ligand-binding domain homology model revealed that the agonist activity of 11Beta-hydroxyprogesterone is caused by contacts between its 11 beta-hydroxyl group and Asn770. Furthermore, 11Beta-hydroxyprogesterone was unable to activate the mutant hMR/N770A, in which Ala is substituted for Asn at position 770. These findings demonstrate that in the absence of the 21-hydroxyl group, the 11 beta-hydroxyl group can produce the contact with the hMR-Asn770 required for the hMR activation leading to stimulated Na(+) absorption.

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11Beta-hydroxyprogesterone ,600-57-7,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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