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[(pF)Phe4]Nociceptin(1-13)NH2

[(pF)Phe4]Nociceptin(1-13)NH2

Catalog No. BCC5778
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1mg $226.00 Ship Within 7 Days
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Quality Control of [(pF)Phe4]Nociceptin(1-13)NH2

Chemical structure

[(pF)Phe4]Nociceptin(1-13)NH2

Biological Activity of [(pF)Phe4]Nociceptin(1-13)NH2

Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.

[(pF)Phe4]Nociceptin(1-13)NH2 Dilution Calculator

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[(pF)Phe4]Nociceptin(1-13)NH2 Molarity Calculator

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Chemical Properties of [(pF)Phe4]Nociceptin(1-13)NH2

Cas No. 380620-88-2 SDF Download SDF
Sequence FGGFTGARKSARK

(Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide)

Chemical Name (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(2,3,4,5,6-pentafluorophenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
SMILES CC(C(C(=O)NCC(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CC1=C(C(=C(C(=C1F)F)F)F)F)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=CC=C2)N)O
Standard InChIKey WLVWYHYEULRQHK-OSTVPBBHSA-N
Standard InChI InChI=1S/C61H95F5N22O15/c1-29(80-42(92)27-79-59(103)49(31(3)90)88-57(101)39(24-33-44(62)46(64)48(66)47(65)45(33)63)82-43(93)26-77-41(91)25-78-53(97)34(69)23-32-13-5-4-6-14-32)51(95)84-38(18-12-22-76-61(73)74)55(99)86-36(16-8-10-20-68)56(100)87-40(28-89)58(102)81-30(2)52(96)85-37(17-11-21-75-60(71)72)54(98)83-35(50(70)94)15-7-9-19-67/h4-6,13-14,29-31,34-40,49,89-90H,7-12,15-28,67-69H2,1-3H3,(H2,70,94)(H,77,91)(H,78,97)(H,79,103)(H,80,92)(H,81,102)(H,82,93)(H,83,98)(H,84,95)(H,85,96)(H,86,99)(H,87,100)(H,88,101)(H4,71,72,75)(H4,73,74,76)/t29-,30-,31+,34-,35-,36-,37-,38-,39-,40-,49-/m0/s1
Formula C61H99FN22O15 M.Wt 1399.6
Solubility Soluble to 2 mg/ml in water
Storage Desiccate at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of [(pF)Phe4]Nociceptin(1-13)NH2

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.7145 mL 3.5724 mL 7.1449 mL 14.2898 mL 17.8622 mL
5 mM 0.1429 mL 0.7145 mL 1.429 mL 2.858 mL 3.5724 mL
10 mM 0.0714 mL 0.3572 mL 0.7145 mL 1.429 mL 1.7862 mL
50 mM 0.0143 mL 0.0714 mL 0.1429 mL 0.2858 mL 0.3572 mL
100 mM 0.0071 mL 0.0357 mL 0.0714 mL 0.1429 mL 0.1786 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Kewords:

[(pF)Phe4]Nociceptin(1-13)NH2,380620-88-2,GPCR/G protein,NOP Receptor, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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