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Catalog No. BCC6599
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50mg $901.00 Ship Within 7 Days
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Quality Control of (RS)-(Tetrazol-5-yl)glycine

Chemical structure


Biological Activity of (RS)-(Tetrazol-5-yl)glycine

Potent NMDA receptor agonist, approximately 20 times more active than NMDA. Also available as part of the Mixed NMDA Receptor.

(RS)-(Tetrazol-5-yl)glycine Dilution Calculator

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(RS)-(Tetrazol-5-yl)glycine Molarity Calculator



Chemical Properties of (RS)-(Tetrazol-5-yl)glycine

Cas No. 138199-51-6 SDF Download SDF
Chemical Name 2-amino-2-(2H-tetrazol-5-yl)acetic acid
SMILES NC(C(O)=O)c1n[nH]nn1 NC(C(O)=O)c1[nH]nnn1
Standard InChI InChI=1S/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
Formula C3H5N5O2 M.Wt 143.1
Solubility Soluble to 50 mM in water
Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (RS)-(Tetrazol-5-yl)glycine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.9881 mL 34.9406 mL 69.8812 mL 139.7624 mL 174.703 mL
5 mM 1.3976 mL 6.9881 mL 13.9762 mL 27.9525 mL 34.9406 mL
10 mM 0.6988 mL 3.4941 mL 6.9881 mL 13.9762 mL 17.4703 mL
50 mM 0.1398 mL 0.6988 mL 1.3976 mL 2.7952 mL 3.4941 mL
100 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.3976 mL 1.747 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (RS)-(Tetrazol-5-yl)glycine

P2 purinoceptor blocker suramin antagonises NMDA receptors and protects against excitatory behaviour caused by NMDA receptor agonist (RS)-(tetrazol-5-yl)-glycine in rats.[Pubmed: 9302084]

It has been reported that suramin, an anthelminthic, trypanocidal agent and an inhibitor of P2 receptors, may antagonise N-methyl-D-aspartate (NMDA) subtype of the excitatory amino acid receptors. Both NMDA receptors and P2X subclass of P2 receptors are ligand-gated Ca2+-selective channels and, since the increased influx of Ca2+ into neurons has been linked to neurotoxicity, simultaneous inhibition of P2X and NMDA receptors in vivo by suramin could represent an effective neuroprotective treatment. We have found that suramin inhibited the binding of [3H]CGP 39653 to NMDA receptor binding sites in vitro and reduced the frequency of NMDA channel openings in patch-clamp studies. Suramin (1 mM) had no effect on [3H]kainate binding in vitro. In vivo, intracerebroventricular (I.C.V.) injections of suramin (70 nmol/brain) antagonised convulsive effects of the NMDA agonist (RS)-(tetrazol-5-yl)-glycine (TZG, LY 285265). Suramin, however, did not prevent neurotoxic lesions in the hippocampus caused by I.C.V. administration of TZG. Increasing the dose of suramin resulted in death from severe respiratory depression.


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