Alpha-hederin as a pro-drug, has cytotoxic and apoptotic/necrotic effects in a dose- and time-dependent manner on on four human cancer cell lines [A549 (lung carcinoma), HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) and MIA PaCa-2 (pancreas carcinoma)] .[1]
Alpha-hederin is a saponin isolated from ivy, has anti-oxidant activity and acute anti-inflammatory activity in carrageenan-induced rat paw edema.[2]
Alpha-hederin, chlorophyllin and ascorbic acid have protective effects towards the induction of micronuclei by doxorubicin in cultured human lymphocytes.[3]
Alpha-hederin has antileishmanial activity ,exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential in Leishmania .[4]
Alpha-hederin affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.[5]
Alpha-Hederin can increase isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like .[6]
Alpha-hederin at sub-IC(50) cytotoxic concentrations enhances 5-fluorouracil (5-FU) cytotoxicity about 3.3-fold, suggests that it is possible to optimize colorectal cancer cell sensitivity to 5-FU with alpha-hederin.[7]
Alpha-hederin has anticancer effect on breast cancer cells.[8]
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[3] Gülçin I, Mshvildadze V, Gepdiremen A,et al. Planta Med, 2004, 70(6):561-3.
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[7] Anne Wolf, Reinoud Gosens, Herman Meurs, et al. Phytother Res Ptr, 2008, 22(10):1299-302.
[8] Cheng L, Xia T S, Wang Y F, et al. Int J Oncol, 2014, 45(2):757-63.
[9] Li Y, Li J, Huang J, et al. Chinese Agr Sci Bull, 2014, 30(13):190-3.
