Tenuifolin

Catalog No. BCN5005
CAS RN 20183-47-5
Molecular Weight 680.8
Molecular Formula C36H56O12
Database [PubChem]:382158079
[ChEBI]:
[PCIDB]:32301

Definition

Standard InChI

InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1

Biological Activity

Tenuifolin is an effective compound from tenuigenin, is commonly used in traditional Chinese herbal medicine for memory loss, has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.[1]
Tenuifolin is one of the active constituents of HPS against the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo, it possesses neuroprotective effects against Aβ25-35-induced apoptosis in PC12 cells and significantly improves the cognitive deficits induced by the intrahippocampal injection of Aβ25-35 in mice. [2]

Product information

English website: Tenuifolin
Japanese website: Tenuifolin
Chinese website: Tenuifolin

References

[1] Lv J, Jia H, Jiang Y, et al. Acta Physiol, 2009, 196(4):419-25.
[2] Liu Y M, Li Z Y, Hu H, et al. Pharmacol Biochem Be, 2015, 128:14-22.
[3] Dong X B, Jun L I, Jiang Y, et al. China journal of Chinese materia medica, 2007, 32(16):1647-9.