Products with Antithrombotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4096 | Darutigenol |
| 1. Darutigenol has obvious antithrombotic effect,its mechanism may be related to inhibition of platelet aggregation and adhesion. | |
| BCN4385 | Rutaecarpine |
| Rutaecarpine is an inhibitor of COX-2 with an IC50 value of 0.28 μM, and is also a potent inhibitor of CYP1A2. Rutaecarpine has anti-atherosclerosis, immunosuppressive, anti-inflammatory, gastroprotective, vasorelaxing, antihypertensive and anti-platelet effects. Rutaecarpine has positive inotropic and chronotropic effects on the guinea-pig isolated right atria, possible involvement of vanilloid receptors. Rutaecarpine may be useful in the prevention of ultraviolet A-induced photoaging, it inhibits ultraviolet A-induced reactive oxygen species generation, resulting in the enhanced expression of matrix metalloproteinase (MMP)-2 and MMP-9 in human skin cells. | |
| BCN4546 | 4-Hydroxybenzoic acid |
| 4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. 4-Hydroxybenzoic acid derivatives has potential to as pan-HDAC inhibitors with anticancer properties. 4-Hydroxybenzoic acid positively regulates the expression of gum cluster to promote EPS production in PXO99A; it can inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL. | |
| BCN4950 | Jujuboside B |
| Jujuboside B has antitumor activity and the underlying mechanism via induction of apoptosis and autophagy. It reduces vascular tension endothelium-dependently by increasing Ca2+Influx and activating endothelial nitric oxide synthase, it has pharmacological effects on improving endothelial dysfunction and treating vascular diseases. | |
| BCN4993 | Diosimin |
| Diosmin is a semisynthetic phlebotropic agent, and also an agonist of the aryl hydrocarbon receptor (AhR). Diosmin can prevent the progression of early diabetic neuropathy in rats, it has cardioprotective effect by the free radical scavenging and anti-hyperlipidaemic effects . | |
