Products with Anti-photoaging bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4876 | Lucidone |
| 1. Lucidone has anti-inflammatory activity, the activity might be caused by the inhibition of iNOS and COX-2 expressions through downregulation of NF-kappaB and AP-1 binding. 2. Lucidone has hepatoprotective effect, it-mediated up-regulation of phase-II enzymes and HO-1 via Nrf-2 signaling pathway may provide a pivotal mechanism for its hepatoprotective action. 3. Lucidone may possess antioxidant and anti-inflammatory properties and may be useful for the prevention of free radical-induced skin damage. 4. Dietary intake of lucidone alleviates high fat diet-induced obesity in C57BL/6 mice and reveals the potential of lucidone as a nutraceutical to prevent obesity and consequent metabolic disorders. 5. Lucidone accelerates wound healing through the cooperation of keratinocyte/fibroblast/ ndothelial cell growth and migration and macrophage inflammation via PI3K/AKT, Wnt/β-catenin and NF-κB signaling cascade activation. 6. Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction, it could be a potential lead or supplement for the development of new anti-HCV agent in the future. | |
| BCN5294 | Norathyriol |
| 1. Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. 2. Norathyriol can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. 3. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation. 4. Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer. 5. Norathyriol may be a dual, yet weak, cyclooxygenase and lipoxygenase pathway blocker, it has anti-inflammatory effect, and has inhibitory effect on the A23187-induced pleurisy and acetic acid-induced writhing response in mice. 6. Norathyriol can relax the rat thoracic aorta mainly by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated calcium channels. | |
| BCN5355 | Aucubin |
| Aucubin is an iridoid glycoside with a wide range of biological activities, including pancreas-protective, chondroprotective, antispasmodic, liver-protective, anti-inflammatory, anti-microbial, antioxidant, anti-algesic as well as anti-tumor activities. Aucubin prevents neuronal death in the hippocampal CA1 region in rats with diabetic encephalopathy, it also has protective effects on H2O2-induced apoptosis in PC12 cells. Aucubin may improve obesity-induced atherosclerosis by attenuating TNF-α-induced inflammatory responses. Aucubin suppresses hepatitis B viral DNA replication in vitro. | |
| BCN5423 | Vitexin |
| Vitexin, an HIF-1alpha inhibitor, which has anticonvulsant, anti-depressant, anti-glycation, spasmolytic, anti-metastatic, antitumor, anti-inflammatory and antinociceptive activities. Vitexin can be effectively used for the prevention of UV-induced adverse skin reactions such as free radical production and skin cell damage; it non-competitively inhibits Ach but not the Ca(2+) influx. | |
| BCN5529 | Brazilin |
| Brazilin exhibits cancer preventive, anti-hepatotoxicity, antiplatelet activity, and anti-inflammatory activities, it also inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing of NF-κB activation in human dermal fibroblasts, thus, it might be used as a potential agent for treatment of UV-induced skin photoaging. Brazilin has anti-IKK activity, can selectively disrupt proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Brazilin induces vasorelaxation by the increasing intracellular Ca(2+) concentration in endothelial cells of blood vessels and hence activating Ca(2+)/calmodulin-dependent NO synthesis. | |
