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E3 Ligase

E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.

Products for E3 Ligase

  1. Cat.No. Product Name Information
  2. BCC4200 CC0651Allosteric inhibitor of hCdc34
  3. BCC6152 SMER 3Selective inhibitor of E3 ubiquitin ligase
  4. BCC6354 PRT 4165Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
  5. BCC7988 NSC 624206Ubiquitin-activating enzyme (E1) inhibitor
  6. BCC8004 SZL P1-41Selective Skp2 inhibitor; suppresses E3 ligase activity

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