HLE

Human leukocyte elastase (HLE), also known as human neutrophil elastase, is a serine protease found abundantly in the azurophilic granules of the neutrophil as well as in monocytes and T cells that preferentially cleaves C-terminal of its substrates into small hydrophobic residues. Encoded by the ELA2 gene, HLE is a highly cationic glycoprotein (218 amino acids) characterized by containing four disulfide bridges and a conserved triad of amino acid residues, including His-41, Asp-88 and Ser-173, within the catalytic domain, which has been found to target a wide variety of substrates, including all components of the extracellular matrix, clotting factors, complement, immunoglobulins and cytokines.

Products for HLE

  1. Cat.No. Product Name Information
  2. BCC1534 DMP 777Leukocyte elastase (HLE) inhibitor

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