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TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Products for TNF-α

  1. Cat.No. Product Name Information
  2. BCC1697 Lenalidomide hydrochlorideTNF-α secretion inhibitor
  3. BCC1793 Necrostatin 2In vitro necroptosis inhibitor
  4. BCC2077 Necrostatin 2 racemateIn vitro necroptosis inhibitor
  5. BCC2078 Necrostatin 2 S enantiomerIn vitro necroptosis inhibitor
  6. BCC2245 Lenalidomide (CC-5013)Antineoplastic agent,inhibits angiogenesis
  7. BCC2246 Pomalidomide (CC-4047)Immunomodulator,antumor/anti-angiogenic
  8. BCC2247 Necrostatin-1Novel inhibitor of non-apoptotic cell death (necroptosis)
  9. BCC4198 Lenalidomide hemihydrate
  10. BCC5355 RoquinimexImmunomodulator with antiangiogenic properties

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