IAP

Inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that suppress apoptosis by binding to and inhibiting caspases 3, 7 and/or 9. Members of IAP family are characterized by a novel baculoviral IAP repeat (BIR) domain (approximate 70 amino acids) in which a conserved cysteine and histidine residues (Cx2Cx6Wx3Dx5Hx6C) represents a novel zinc-binding fold. However, not all proteins with BIR domain qualify to be an IAP family member. The ability to suppress apoptosis is required as well. So far, eight members of human IAP family have been identified, which are divided into three classes, including class I (XIAP, cIAP1, cIAP2, ILP2 and MLIAP), class II (NAIP) and class III (SURVIVIN and BRUCE).

Products for IAP

  1. Cat.No. Product Name Information
  2. BCN2678 Embelin Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor
  3. BCC1283 AT-406 (SM-406)IAP inhibitor
  4. BCC1691 LCL161Antagonist of IAPs inhibitor
  5. BCC2250 Birinapant (TL32711)Potent XIAP/cIAP1 antagonist
  6. BCC2251 YM155Survivin suppressant,apoptosis inhibitor
  7. BCC2252 GDC-0152IAP antagonist,potent amd samll-molecule
  8. BCC4002 SM-164Anticancer agent
  9. BCC5372 BV6Selective inhibitor of IAP proteins

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