ViroallosecurinineCAS# 1857-30-3 |
- Allosecurinin
Catalog No.:BCX0884
CAS No.:884-68-4
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1857-30-3 | SDF | Download SDF |
| PubChem ID | 267769 | Appearance | Powder |
| Formula | C13H15NO2 | M.Wt | 217.27 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4 | ||
| Standard InChIKey | SWZMSZQQJRKFBP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Virosecurinine and viroallosecurinine were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. 2. Viroallosecurinine exhibits a MIC of 0.48 micrograms/ml for Pseudomonas aeruginosa and Staphylococcus aureus. |
| Targets | Antifection |
Viroallosecurinine Dilution Calculator
Viroallosecurinine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.6026 mL | 23.0128 mL | 46.0257 mL | 92.0514 mL | 115.0642 mL |
| 5 mM | 0.9205 mL | 4.6026 mL | 9.2051 mL | 18.4103 mL | 23.0128 mL |
| 10 mM | 0.4603 mL | 2.3013 mL | 4.6026 mL | 9.2051 mL | 11.5064 mL |
| 50 mM | 0.0921 mL | 0.4603 mL | 0.9205 mL | 1.841 mL | 2.3013 mL |
| 100 mM | 0.046 mL | 0.2301 mL | 0.4603 mL | 0.9205 mL | 1.1506 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.[Pubmed:1865332]
J Pharm Sci. 1991 Apr;80(4):325-7.
Virosecurinine (1) and Viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.
Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids.[Pubmed:17365714]
Nat Prod Res. 2007 Mar;21(3):234-42.
Investigations on callus cultures of Securinega suffruticosa indicated that the cell line of S. suffruticosa callus was able to accumulate four known Securinega alkaloids with dextro rotation but not levo rotation as reported before: virosecurinine (1), Viroallosecurinine (2), 14,15-dihydrovirosecurinine (3) and ent-phyllanthidine (4). Time course studies on the growth of callus cultures were carried out. The effects of different plant growth regulators, sucrose concentrations on callus growth and virosecurinine production were also reported.
Antibacterial activity of the leaves of Phyllanthus discoideus.[Pubmed:2156112]
J Ethnopharmacol. 1990 Feb;28(1):129-33.
The lyophilized aqueous extract (LWE) from the leaves of Phyllanthus discoideus was found to show an antibacterial activity. The alkaloid fraction obtained from LWE inhibited the growth of Escherichia coli and Enterococcus faecium (MIC = 1.6 mg/ml), Pseudomonas aeruginosa (MIC = 0.78 mg/ml), Staphylococcus aureus and Mycobacterium smegmatis (MIC = 0.2 mg/ml). Among the alkaloids identified, Viroallosecurinine and securinine showed a high activity. Viroallosecurinine exhibited a MIC of 0.48 micrograms/ml for Ps. aeruginosa and Staph. aureus. This alkaloid is bactericidal since the yields of MIC/MBC were less than 1. The MIC of securinine was 0.500 mg/ml for E. coli, Staph. aureus and Myc. smegmatis. These effects of Phyllanthus discoideus leaf extracts support some of the local uses of the plant in traditional therapy.
