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Tartrazine

CAS# 1934-21-0

Tartrazine

Catalog No. BCN2217----Order now to get a substantial discount!

Product Name & Size	Price	Stock
Tartrazine:100mg	$67.00	In stock
Tartrazine:200mg	$114.00	In stock
Tartrazine:500mg	$268.00	In stock
Tartrazine:1000mg	$469.00	In stock

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Quality Control of Tartrazine

Quality Control & MSDS

Purity: >98%

Number of papers citing our products

Chemical structure

3D structure

Chemical Properties of Tartrazine

Cas No.	1934-21-0	SDF	Download SDF
PubChem ID	164825	Appearance	Yellow powder
Formula	C16H9N4Na3O9S2	M.Wt	534.36
Type of Compound	Miscellaneous	Storage	Desiccate at -20°C
Synonyms	Acid Yellow 23; FD&C; Yellow 5; C.I. 19140
Solubility	DMSO : 10 mg/mL (18.71 mM; Need ultrasonic and warming);
Chemical Name	trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4H-pyrazole-3-carboxylate
SMILES	C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)[O-])C(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+]
Standard InChIKey	UJMBCXLDXJUMFB-UHFFFAOYSA-K
Standard InChI	InChI=1S/C16H12N4O9S2.3Na/c21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;;;/h1-8,13H,(H,22,23)(H,24,25,26)(H,27,28,29);;;/q;3*+1/p-3
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Tartrazine

Description

Tartrazine is a food additive that belongs to a class of artificial dyes and contains an azo group; it has significant genotoxic effect , may be harmful to health and its prolonged use could trigger carcinogenesis.

In vitro

Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow.[Pubmed: 25750299]

Anticancer Res. 2015 Mar;35(3):1465-74.

Tartrazine is a food additive that belongs to a class of artificial dyes and contains an azo group. Studies about its genotoxic, cytotoxic and mutagenic effects are controversial and, in some cases, unsatisfactory. This work evaluated the potential in vitro cytotoxicity, genotoxicity and effects on DNA repair of human lymphocytes exposed to the dye.
METHODS AND RESULTS:
We assessed the cytotoxicity of Tartrazine by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide test and the response of DNA repair through comet assay (alkaline version). We used different concentrations of the dye, ranging from 0.25-64.0 mM. The results demonstrated that Tartrazine has no cytotoxic effects. However, this dye had a significant genotoxic effect at all concentrations tested. Although most of the damage was amenable to repair, some damage remained higher than positive control after 24 h of repair.
CONCLUSIONS:
These data demonstrate that Tartrazine may be harmful to health and its prolonged use could trigger carcinogenesis.

Assessment of the breakdown products of solar/UV induced photolytic degradation of food dye tartrazine.[Pubmed: 24704040]

Food Chem Toxicol. 2014 Jun;68:307-15.

METHODS AND RESULTS:
The food dye Tartrazine (CI 19140) was exposed to UV irradiation from an artificial source, a mercury vapor lamp, and a natural one, sunlight. It was observed that conditions such as energy dose, irradiation time, pH and initial dye concentration affected its discoloration. There was 100% of color removal, after 30min of irradiation, when a dye solution 1×10(-5)molL(-1) was submitted to an energy dose of 37.8Jcm(-2). Liquid Chromatography coupled to Diode Array Detection and Mass Spectrometry confirmed the cleavage of the chromophore group and the formation of five by-products at low concentration.
CONCLUSIONS:
Although by-products were formed, the Salmonella/microsome mutagenicity assay performed for both, the dye solution at a dose of 5.34mg/plate and the solutions obtained after exposure to UV irradiation, did not present mutagenic activity for TA98 and TA100 with and without S9.

In vivo

Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats.[Pubmed: 20678534 ]

Food Chem Toxicol. 2010 Oct;48(10):2994-9

Tartrazine and carmoisine are an organic azo dyes widely used in food products, drugs and cosmetics. The present study conducted to evaluate the toxic effect of these coloring food additives; on renal, hepatic function, lipid profile, blood glucose, body-weight gain and biomarkers of oxidative stress in tissue.
METHODS AND RESULTS:
Tartrazine and carmoisine were administered orally in two doses, one low and the other high dose for 30 days followed by serum and tissue sample collection for determination of ALT, AST, ALP, urea, creatinine, total protein, albumin, lipid profile, fasting blood glucose in serum and estimation of GSH, catalase, SOD and MDA in liver tissue in male albino rat. Our data showed a significant increase in ALT, AST, ALP, urea, creatinine total protein and albumin in serum of rats dosed with Tartrazine and carmoisine compared to control rats and these significant change were more apparent in high doses than low, GSH, SOD and Catalase were decreased and MDA increased in tissue homogenate in rats consumed high Tartrazine and both doses of carmoisine.
CONCLUSIONS:
We concluded that Tartrazine and carmoisine affect adversely and alter biochemical markers in vital organs e.g. liver and kidney not only at higher doses but also at low doses.

Protocol of Tartrazine

Structure Identification

Luminescence. 2014 Mar;29(2):195-200.

A probe to study the toxic interaction of tartrazine with bovine hemoglobin at the molecular level.[Pubmed: 23653408]

Tartrazine is an artificial azo dye commonly used in food products, but Tartrazine in the environment is potentially harmful.
METHODS AND RESULTS:
The toxic interaction between Tartrazine and bovine hemoglobin (BHb) was investigated using fluorescence, synchronous fluorescence, UV-vis absorption, circular dichroism (CD) and molecular modeling techniques under simulated physiological conditions. The fluorescence data showed that Tartrazine can bind with BHb to form a complex. The binding process was a spontaneous molecular interaction, in which van der Waals' forces and hydrogen bonds played major roles. Molecular docking results showed that the hydrogen bonds exist between the oxygen atoms at position 31 of Tartrazine and the nitrogen atom NZ7 on Lys99, and also between the oxygen atoms at position 15 of Tartrazine and the nitrogen atom NZ7 on Lys104, Lys105.
CONCLUSIONS:
The results of UV-vis and CD spectra revealed that Tartrazine led to conformational changes in BHb, including loosening of the skeleton structure and decreasing α helix in the secondary structure. The synchronous fluorescence experiment revealed that Tartrazine binds into the hemoglobin central cavity, and this was verified using a molecular modeling study.

Tartrazine Dilution Calculator

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Preparing Stock Solutions of Tartrazine

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8714 mL	9.357 mL	18.714 mL	37.428 mL	46.7849 mL
5 mM	0.3743 mL	1.8714 mL	3.7428 mL	7.4856 mL	9.357 mL
10 mM	0.1871 mL	0.9357 mL	1.8714 mL	3.7428 mL	4.6785 mL
50 mM	0.0374 mL	0.1871 mL	0.3743 mL	0.7486 mL	0.9357 mL
100 mM	0.0187 mL	0.0936 mL	0.1871 mL	0.3743 mL	0.4678 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Tartrazine

Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. Tartrazine is water-soluble and has a maximum absorbance in an aqueous solution at 425 nm.