Stavudine sodiumCAS# 134624-73-0 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 134624-73-0 | SDF | Download SDF |
| PubChem ID | 78358329 | Appearance | Powder |
| Formula | C10H11N2NaO4 | M.Wt | 246.2 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | d4T sodium | ||
| Solubility | Soluble in DMSO | ||
| Chemical Name | sodium;[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methanolate | ||
| SMILES | CC1=CN(C(=O)NC1=O)C2C=CC(O2)C[O-].[Na+] | ||
| Standard InChIKey | NPETYOHVRRLVHG-KZYPOYLOSA-N | ||
| Standard InChI | InChI=1S/C10H11N2O4.Na/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8;/h2-4,7-8H,5H2,1H3,(H,11,14,15);/q-1;+1/t7-,8+;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Target: HIV RT; NRTIs
Stavudine sodium is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine sodium is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine sodium triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it [1].
Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes [2].
Clinical indications: HIV-1 infection
FDA Approved Date: June 24, 1994
Toxicity: peripheral neuropathy; lipodystrophy References: | |||||
Stavudine sodium Dilution Calculator
Stavudine sodium Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0617 mL | 20.3087 mL | 40.6174 mL | 81.2348 mL | 101.5435 mL |
| 5 mM | 0.8123 mL | 4.0617 mL | 8.1235 mL | 16.247 mL | 20.3087 mL |
| 10 mM | 0.4062 mL | 2.0309 mL | 4.0617 mL | 8.1235 mL | 10.1543 mL |
| 50 mM | 0.0812 mL | 0.4062 mL | 0.8123 mL | 1.6247 mL | 2.0309 mL |
| 100 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 0.8123 mL | 1.0154 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
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Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
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