Songoramine

CAS# 23179-78-4

Songoramine

Catalog No. BCN6474----Order now to get a substantial discount!

Product Name & Size Price Stock
Songoramine: 5mg $799 In Stock
Songoramine: 10mg Please Inquire In Stock
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Quality Control of Songoramine

Number of papers citing our products

Chemical structure

Songoramine

3D structure

Chemical Properties of Songoramine

Cas No. 23179-78-4 SDF Download SDF
PubChem ID 14526618 Appearance Powder
Formula C22H29NO3 M.Wt 355.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 11-ethyl-19-hydroxy-5-methyl-18-methylidene-9-oxa-11-azaheptacyclo[15.2.1.01,14.02,12.04,13.05,10.08,13]icosan-16-one
SMILES CCN1C2C3CC4C2(C5CCC4(C1O5)C)C6C37CC(C(=C)C7O)C(=O)C6
Standard InChIKey YSSPOBAEOOLGAT-UHFFFAOYSA-N
Standard InChI InChI=1S/C22H29NO3/c1-4-23-17-12-7-14-20(3)6-5-16(26-19(20)23)22(14,17)15-8-13(24)11-9-21(12,15)18(25)10(11)2/h11-12,14-19,25H,2,4-9H2,1,3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Songoramine

The roots of Aconitum brachypodum

Biological Activity of Songoramine

Description1. Songoramine(10 uM) demonstrates significant hERG K+ channel inhibition.
TargetsPotassium Channel

Songoramine Dilution Calculator

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Songoramine Molarity Calculator

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Preparing Stock Solutions of Songoramine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8129 mL 14.0647 mL 28.1294 mL 56.2588 mL 70.3235 mL
5 mM 0.5626 mL 2.8129 mL 5.6259 mL 11.2518 mL 14.0647 mL
10 mM 0.2813 mL 1.4065 mL 2.8129 mL 5.6259 mL 7.0323 mL
50 mM 0.0563 mL 0.2813 mL 0.5626 mL 1.1252 mL 1.4065 mL
100 mM 0.0281 mL 0.1406 mL 0.2813 mL 0.5626 mL 0.7032 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Songoramine

Diterpene alkaloids from Aconitum anthora and assessment of the hERG-inhibiting ability of Aconitum alkaloids.[Pubmed:20862641]

Planta Med. 2011 Mar;77(4):368-73.

A new norditerpene alkaloid, 10-hydroxy-8- O-methyltalatizamine (1), was isolated from the whole plant of ACONITUM ANTHORA L. besides the known isotalatizidine (2) and hetisinone (3). The structures were determined by means of HR-ESI-MS, 1D and 2D NMR spectroscopy, including (1)H-(1)H COSY, NOESY, HSQC and HMBC experiments, resulting in complete (1)H and (1)(3)C chemical shift assignments for 1- 3, and revision of some earlier (1)(3)C-NMR data. The effects of the isolated compounds, together with twenty-one other ACONITUM alkaloids with different skeletal types and substitution patterns, on hERG channels were studied by the whole-cell patch clamp technique, using the QPatch-16 automated patch clamp system. At 10 microM, aconitine, 14-benzoylaconine 8- O-palmitate, Songoramine, gigactonine and neolinine demonstrated significant hERG K+ channel inhibition; all other compounds exerted only low (6-21%) inhibitory activity.

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