Shizukaol D

CAS# 142279-42-3

Shizukaol D

Catalog No. BCN6226----Order now to get a substantial discount!

Product Name & Size Price Stock
Shizukaol D: 5mg $1098 In Stock
Shizukaol D: 10mg Please Inquire In Stock
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Quality Control of Shizukaol D

Number of papers citing our products

Chemical structure

Shizukaol D

3D structure

Chemical Properties of Shizukaol D

Cas No. 142279-42-3 SDF Download SDF
PubChem ID 70698151 Appearance Powder
Formula C33H38O9 M.Wt 578.7
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (2Z)-2-[(1R,2S,8S,9R,10S,12R,13S,14S,17S,19R,20S,21R)-9-(acetyloxymethyl)-21-hydroxy-5-(hydroxymethyl)-13,20-dimethyl-4,22-dioxo-3-oxaoctacyclo[14.7.1.02,6.02,14.08,13.010,12.017,19.020,24]tetracosa-5,16(24)-dien-23-ylidene]propanoate
SMILES CC(=C1C2C3=C(CC4C25C(=C(C(=O)O5)CO)CC6C4(C7CC7C6COC(=O)C)C)C8CC8C3(C(C1=O)O)C)C(=O)OC
Standard InChIKey UEHIWILSQZCXQY-LWKKLXHHSA-N
Standard InChI InChI=1S/C33H38O9/c1-12(29(38)40-5)24-26-25-16(14-6-20(14)32(25,4)28(37)27(24)36)8-23-31(3)19-7-15(19)18(11-41-13(2)35)21(31)9-22-17(10-34)30(39)42-33(22,23)26/h14-15,18-21,23,26,28,34,37H,6-11H2,1-5H3/b24-12-/t14-,15-,18-,19-,20-,21+,23+,26+,28+,31+,32+,33+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Shizukaol D

The herbs of Chloranthus japonicus

Biological Activity of Shizukaol D

Description1. Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. 2. Shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation, suggests that shizukaol D may be used to treat metabolic syndrome.
TargetsAMPK

Shizukaol D Dilution Calculator

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Shizukaol D Molarity Calculator

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Preparing Stock Solutions of Shizukaol D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.728 mL 8.6401 mL 17.2801 mL 34.5602 mL 43.2003 mL
5 mM 0.3456 mL 1.728 mL 3.456 mL 6.912 mL 8.6401 mL
10 mM 0.1728 mL 0.864 mL 1.728 mL 3.456 mL 4.32 mL
50 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.6912 mL 0.864 mL
100 mM 0.0173 mL 0.0864 mL 0.1728 mL 0.3456 mL 0.432 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Shizukaol D

Shizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunction.[Pubmed:23967345]

PLoS One. 2013 Aug 14;8(8):e73527.

This study is the first to demonstrate that Shizukaol D, a natural compound isolated from Chloranthusjaponicus, can activate AMP- activated protein kinase (AMPK), a key sensor and regulator of intracellular energy metabolism, leading to a decrease in triglyceride and cholesterol levels in HepG2 cells. Furthermore, we found that Shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. Our results provide a possible link between mitochondrial dysfunction and AMPK activation and suggest that Shizukaol D might be used to treat metabolic syndrome.

Spicachlorantins G-J, new lindenane sesquiterpenoid dimers from the roots of Chloranthus spicatus.[Pubmed:21963639]

Chem Pharm Bull (Tokyo). 2011;59(10):1281-4.

Four new lindenane sesquiterpenoid dimers, spicachlorantins G-J (1-4), were isolated from the roots of Chloranthus spicatus together with seven known compounds, including chloramultilide A, shizukaol B, Shizukaol D, shizukaol F, shizukaol P, chlorahololide D, and cycloshizukaol A. The planar structures of the new compounds were established by 1D-, 2D-NMR, and MS analyses. The absolute configurations of these compounds were determined by analyzing rotating Overhauser enhancement and exchange spectroscopy (ROESY) and circular dichroism (CD) spectra.

Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.[Pubmed:27010735]

PLoS One. 2016 Mar 24;11(3):e0152012.

Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that Shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that Shizukaol D induced cells to undergo apoptosis. More importantly, Shizukaol D attenuated Wnt signalling and reduced the expression of endogenous Wnt target genes, which resulted in decreased expression of beta-catenin. Collectively, this study demonstrated that Shizukaol D inhibited the growth of liver cancer cells by modulating Wnt pathway.

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