Lobelin

CAS# 90-69-7

Lobelin

Catalog No. BCN2157----Order now to get a substantial discount!

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Quality Control of Lobelin

Number of papers citing our products

Chemical structure

Lobelin

3D structure

Chemical Properties of Lobelin

Cas No. 90-69-7 SDF Download SDF
PubChem ID 101616 Appearance Powder
Formula C22H27NO2 M.Wt 337.46
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone
SMILES CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O
Standard InChIKey MXYUKLILVYORSK-HBMCJLEFSA-N
Standard InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lobelin

The herbs of Lobelia sessilifolia Lamb.

Biological Activity of Lobelin

Description1. Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing.
TargetsAChR | Antifection

Lobelin Dilution Calculator

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Lobelin Molarity Calculator

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Preparing Stock Solutions of Lobelin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9633 mL 14.8166 mL 29.6331 mL 59.2663 mL 74.0829 mL
5 mM 0.5927 mL 2.9633 mL 5.9266 mL 11.8533 mL 14.8166 mL
10 mM 0.2963 mL 1.4817 mL 2.9633 mL 5.9266 mL 7.4083 mL
50 mM 0.0593 mL 0.2963 mL 0.5927 mL 1.1853 mL 1.4817 mL
100 mM 0.0296 mL 0.1482 mL 0.2963 mL 0.5927 mL 0.7408 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lobelin

[Effect of cholinergic substances on nociceptive evoked responses in specific thalamic nuclei].[Pubmed:7439367]

Farmakol Toksikol. 1980 Jul-Aug;43(4):360-3.

The effect of the M-cholinomimetic arecoline and M-cholinolytic metamizil, n-cholinomimetic Lobelin and n-cholinolytic -506 (beta-ethylenespasmolytin) on the formation of nociceptive responses induced by dental pulp stimulation was studied by means of microinjections into the rabbit thalamus preparations VPM and VPL. Arecoline and -506 decreased while metamizil and Lobelin increased the amplitude of the primary responses. No changes in the latent periods were noted. It is concluded that the activation of the M-cholinergic structures of specific nuclei of the thalamus reduces the nociceptive responses. The activation of the N-cholinergic structures potentiates the nociceptive responses in specific relays.

[Case report of collagen lung in SLE presenting with cough variant asthma: relation between the localization of responsible receptors and cough].[Pubmed:1569725]

Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Mar;30(3):453-7.

A 27-year-old nonsmoking woman complained of cough and chest oppression for two years since an episode of pneumonia. Clinical tests showed decrease in FEV1.0 during attacks of coughing and evidence of bronchial hypersensitivity. While these events fitted the picture of bronchial asthma, the nonwheezing cough suggested cough variant asthma. Antinuclear antibody and anti-ds DNA antibody were increased and leukopenia was recognized, suggesting the diagnosis of systemic lupus erythematosus (SLE). Bronchoalveolar lavage showed lymphocytic alveolitis and decreased T4/T8. These results were suggestive of collagen lung induced by SLE. Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing. We conclude that the peripheral lesion of collagen lung stimulates the peripheral c-fiber receptors, leading to cough variant asthma.

The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices.[Pubmed:11469511]

Vet Res Commun. 2001 Jul;25(5):401-12.

Several indices of ventilatory heterogeneity can be identified from the volumetric capnogram and its graphic presentation, the single-breath diagram for CO2 (SBD-CO2). Physiologically based indices of pulmonary function (VTE, VCO2, FACO2, VDBohr% VDBohr%, VD/VTE, A1/A2) were calculated for healthy horses (group I, n = 5) and for horses with subclinical (group II, n = 7) or clinically manifest chronic obstructive pulmonary disease (COPD) (group III, n = 8) during tidal breathing and after medication with Lobelin hydrochloride (Lobelin). We investigated the variability and repeatability of the lung function indices in healthy horses and in those with COPD both during tidal breathing and after administration of Lobelin, a centrally acting respiratory stimulant. In particular, we were interested in whether the discriminating ability of SBD-CO2-derived lung function indices would be increased between different patient groups after administration of Lobelin compared to those for the resting values. Of the indices studied, VTE, FACO, VDBohr% and A1/A2 appeared to be those with good to excellent repeatability in discriminating healthy horses from those with COPD. Stimulating respiration with Lobelin gave no advantage in the repeatability of the lung function indices or in differentiating between horses with different degrees of COPD.

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