LigustroflavoneCAS# 260413-62-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 260413-62-5 | SDF | Download SDF |
| PubChem ID | 10417462 | Appearance | White-yellowish powder |
| Formula | C33H40O18 | M.Wt | 724.67 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | Nuezhenoside | ||
| Solubility | DMSO : 250 mg/mL (344.99 mM; Need ultrasonic) | ||
| Chemical Name | 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one | ||
| SMILES | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)OC6C(C(C(C(O6)C)O)O)O)O)O)O)O)O | ||
| Standard InChIKey | NULBHTHMVOCGOE-ZBCCAYPVSA-N | ||
| Standard InChI | InChI=1S/C33H40O18/c1-11-22(37)25(40)28(43)31(46-11)45-10-20-24(39)27(42)30(51-32-29(44)26(41)23(38)12(2)47-32)33(50-20)48-15-7-16(35)21-17(36)9-18(49-19(21)8-15)13-3-5-14(34)6-4-13/h3-9,11-12,20,22-35,37-44H,10H2,1-2H3/t11-,12-,20+,22-,23-,24+,25+,26+,27-,28+,29+,30+,31+,32-,33+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ligustroflavone shows high antioxidant capacity and is reported to be an AMPK activator, it activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK. |
| Targets | AMPK | ATP |
| In vitro | Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985]J Ethnopharmacol. 2000 Jun;70(3):213-7.
Identification of Glycosil Flavones and Determination in vitro of Antioxidant and Photoprotective Activities of Alternanthera brasiliana L. Kuntze.[Reference: WebLink]Research Journal of Phytochemistry, 2014, 8(4):148-154.
The study Alternanthera brasiliana (L.) Kuntze aims to prove its effectiveness in folk medicine. |
| Kinase Assay | Assembly of Adiponectin with Ligustroflavone by Activating AMPK.[Reference: WebLink]Chinese Journal of Experimental Traditional Medical Formulae, 2016(1):18-21.To investigate activation mechanism of AMPK [adenosine 5'-monophosphate( AMP)-activated protein kinase] by Ligustroflavone,and explore effect of Ligustroflavone on assembly of adiponectin. |
| Structure Identification | Pharmazie. 2000 Jan;55(1):78-80.Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed: 10683879]A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated. |
Ligustroflavone Dilution Calculator
Ligustroflavone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3799 mL | 6.8997 mL | 13.7994 mL | 27.5988 mL | 34.4985 mL |
| 5 mM | 0.276 mL | 1.3799 mL | 2.7599 mL | 5.5198 mL | 6.8997 mL |
| 10 mM | 0.138 mL | 0.69 mL | 1.3799 mL | 2.7599 mL | 3.4498 mL |
| 50 mM | 0.0276 mL | 0.138 mL | 0.276 mL | 0.552 mL | 0.69 mL |
| 100 mM | 0.0138 mL | 0.069 mL | 0.138 mL | 0.276 mL | 0.345 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed:10837985]
J Ethnopharmacol. 2000 Jun;70(3):213-7.
Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system. Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and Ligustroflavone presented remarkable activity.
Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed:10683879]
Pharmazie. 2000 Jan;55(1):78-80.
A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated.
