Kihadanin BCAS# 73793-68-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 73793-68-7 | SDF | Download SDF |
| PubChem ID | 156766 | Appearance | Powder |
| Formula | C26H30O9 | M.Wt | 486.5 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1(C2CC(=O)C3(C(C2(C=CC(=O)O1)C)CCC4(C35C(O5)C(=O)OC4C6=CC(OC6=O)O)C)C)C | ||
| Standard InChIKey | LUSHRJRLUBDDTB-KNQGVANASA-N | ||
| Standard InChI | InChI=1S/C26H30O9/c1-22(2)14-11-15(27)25(5)13(23(14,3)8-7-16(28)34-22)6-9-24(4)18(12-10-17(29)32-20(12)30)33-21(31)19-26(24,25)35-19/h7-8,10,13-14,17-19,29H,6,9,11H2,1-5H3/t13-,14+,17?,18+,19-,23-,24+,25+,26-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes. |
| Targets | Akt | PPAR |
Kihadanin B Dilution Calculator
Kihadanin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0555 mL | 10.2775 mL | 20.555 mL | 41.11 mL | 51.3875 mL |
| 5 mM | 0.4111 mL | 2.0555 mL | 4.111 mL | 8.222 mL | 10.2775 mL |
| 10 mM | 0.2055 mL | 1.0277 mL | 2.0555 mL | 4.111 mL | 5.1387 mL |
| 50 mM | 0.0411 mL | 0.2055 mL | 0.4111 mL | 0.8222 mL | 1.0277 mL |
| 100 mM | 0.0206 mL | 0.1028 mL | 0.2055 mL | 0.4111 mL | 0.5139 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Chemical constituents from root barks of Dictamnus dasycarpus and their cytotoxic activities].[Pubmed:30717533]
Zhongguo Zhong Yao Za Zhi. 2018 Dec;43(24):4869-4877.
Nineteen compounds, including kihadanin D (1), obacunone (2), kihadanin A (3), Kihadanin B (4), kihadanin C (5), limonin (6), evodol (7), fraxinellone (8), furo[2,3-b]quinolin-4-ol (9), preskimmianine (10), ifflaiamine (11), dictamnol (12), naringenin (13), diosmetin (14), wogonin (15), scopoletin (16), cleomiscosin A (17), apocynin (18), and methyl pyroglutamate (19), were isolated from the methanol extract of the root barks of Dictamnus dasycarpus by using various column chromatographies. Their chemical structures were extensively determined on basis of UV, IR, NMR, MS, and CD spectroscopic data analyses. Among them, 1 is a new limonoid, 9 was isolated from plant kingdom for the first time, 11, 13-14 and 17-19 were obtained from the genus Dictamnnus for the first time. Cytotoxicities of compounds 1-18 were tested, and the results indicated that 1 exhibited cytotoxicities against three human cancer cell lines MDA-MB-231, A549 and HT29 with IC(5)(8) values of 16.22, 21.72 and 31.06 mumol.L(-)(1), respectively.
A Limonoid Kihadanin B from Immature Citrus unshiu Peels Suppresses Adipogenesis through Repression of the Akt-FOXO1-PPARgamma Axis in Adipocytes.[Pubmed:27977180]
J Agric Food Chem. 2016 Dec 28;64(51):9607-9615.
Citrus limonoids are secondary metabolites and exhibit a variety of biological activities. In this study, we elucidated the suppression of adipogenesis by a Citrus limonoid Kihadanin B and determined its molecular mechanism in mouse 3T3-L1 adipocytes. Kihadanin B was purified from the peels of immature Citrus unshiu by HPLC, and its chemical structure was determined by NMR and mass spectrometry. Kihadanin B reduced the lipid accumulation with the reduction of the expression levels of the adipogenic and lipogenic genes, but did not affect lipolysis in adipocytes. Phosphorylation levels of Akt and a forkhead transcriptional factor, FOXO1, a repressor of PPARgamma, were lowered by Kihadanin B. Furthermore, Kihadanin B increased the binding level of FOXO1 to the PPARgamma gene promoter in adipocytes. These results indicate that a Citrus limonoid Kihadanin B repressed the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARgamma axis in 3T3-L1 adipocytes.
[Chemical constituents from the twigs and leaves of Harrisonia perforate].[Pubmed:27169286]
Yao Xue Xue Bao. 2015 Dec;50(12):1622-4.
This study was performed to investigate the chemical constituents in the twigs and leaves of Harrisonia perforate. Six compounds were isolated from the 95% EtOH extract of the twigs and leaves of Harrisonia perforate by silica gel, ODS, Sephadex LH-20 column chromatographies and preparative HPLC. On the basis of chemical properties and spectra data, these compounds were identified as harriperfin E (1), kihadanin A (2), Kihadanin B (3), 6alpha-acetoxyobacunol acetate (4), gardaubryone C (5), and beta-sitosterol methyl ether (6), respectively. Compound 1 is a new chromone, and compounds 2-6 are isolated from this plant for the first time.
