H-D-Pen-OH

CAS# 52-67-5

H-D-Pen-OH

Catalog No. BCC3307----Order now to get a substantial discount!

Product Name & Size Price Stock
H-D-Pen-OH:25mg $38.00 In stock
H-D-Pen-OH:50mg $65.00 In stock
H-D-Pen-OH:125mg $152.00 In stock
H-D-Pen-OH:250mg $266.00 In stock
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Quality Control of H-D-Pen-OH

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Chemical structure

H-D-Pen-OH

3D structure

Chemical Properties of H-D-Pen-OH

Cas No. 52-67-5 SDF Download SDF
PubChem ID 5852 Appearance Powder
Formula C5H11NO2S M.Wt 149.2
Type of Compound N/A Storage Desiccate at -20°C
Synonyms D-Penicillamine; Penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine
Solubility H2O : 50 mg/mL (335.10 mM; Need ultrasonic)
DMSO : 1.43 mg/mL (9.58 mM; Need ultrasonic)
Chemical Name (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
SMILES CC(C)(C(C(=O)O)N)S
Standard InChIKey VVNCNSJFMMFHPL-VKHMYHEASA-N
Standard InChI InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of H-D-Pen-OH

DescriptionPenicillamine is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease. Target: Others Penicillamine(Cuprimine, Depen) is used as an antirheumatic and as a chelating agent in Wilson's disease and is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine. Penicillamine also reduces excess cystine excretion in cystinuria. The mechanism of action of penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity [1-3].

References:
[1]. Peisach, J. and W.E. Blumberg, A mechanism for the action of penicillamine in the treatment of Wilson's disease. Mol Pharmacol, 1969. 5(2): p. 200-9. [2]. Jaffe, I.A., K. Altman, and P. Merryman, The Antipyridoxine Effect of Penicillamine in Man. J Clin Invest, 1964. 43: p. 1869-73. [3]. Camp, A.V., Penicillamine in the treatment of rheumatoid arthritis. Proc R Soc Med, 1977. 70(2): p. 67-9.

H-D-Pen-OH Dilution Calculator

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H-D-Pen-OH Molarity Calculator

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Preparing Stock Solutions of H-D-Pen-OH

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.7024 mL 33.5121 mL 67.0241 mL 134.0483 mL 167.5603 mL
5 mM 1.3405 mL 6.7024 mL 13.4048 mL 26.8097 mL 33.5121 mL
10 mM 0.6702 mL 3.3512 mL 6.7024 mL 13.4048 mL 16.756 mL
50 mM 0.134 mL 0.6702 mL 1.3405 mL 2.681 mL 3.3512 mL
100 mM 0.067 mL 0.3351 mL 0.6702 mL 1.3405 mL 1.6756 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on H-D-Pen-OH

H-D-Pen-OH

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Description

Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics.

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