GlabroneCAS# 60008-02-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 60008-02-8 | SDF | Download SDF |
| PubChem ID | 5317652 | Appearance | Powder |
| Formula | C20H16O5 | M.Wt | 336.34 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 7-hydroxy-3-(5-hydroxy-2,2-dimethylchromen-6-yl)chromen-4-one | ||
| SMILES | CC1(C=CC2=C(O1)C=CC(=C2O)C3=COC4=C(C3=O)C=CC(=C4)O)C | ||
| Standard InChIKey | COLMVFWKLOZOOP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H16O5/c1-20(2)8-7-14-16(25-20)6-5-12(18(14)22)15-10-24-17-9-11(21)3-4-13(17)19(15)23/h3-10,21-22H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Glabrone shows antiviral activity against influenza virus. 2. Glabrone exhibits significant PPAR-gamma ligand-binding activity. |
| Targets | Influenza virus | PPAR |
Glabrone Dilution Calculator
Glabrone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9732 mL | 14.8659 mL | 29.7318 mL | 59.4636 mL | 74.3295 mL |
| 5 mM | 0.5946 mL | 2.9732 mL | 5.9464 mL | 11.8927 mL | 14.8659 mL |
| 10 mM | 0.2973 mL | 1.4866 mL | 2.9732 mL | 5.9464 mL | 7.433 mL |
| 50 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.1893 mL | 1.4866 mL |
| 100 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.5946 mL | 0.7433 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Bruceoside A
Catalog No.:BCN8638
CAS No.:63306-30-9
- Veratrosine
Catalog No.:BCN8637
CAS No.:475-00-3
- (Z)-Aldosecologanin
Catalog No.:BCN8636
CAS No.:82474-97-3
- Dihydrolicoisoflavone
Catalog No.:BCN8635
CAS No.:164163-92-2
- Kushenol S
Catalog No.:BCN8634
CAS No.:254886-72-1
- 2,3,4,5-Tetracaffeoyl-D-glucaric acid
Catalog No.:BCN8633
CAS No.:1419478-52-6
- Saikosaponin E
Catalog No.:BCN8632
CAS No.:64340-44-9
- 2-Amino-N-(2-bromophenyl)benzamide
Catalog No.:BCN8631
CAS No.:34489-85-5
- Glyasperin F
Catalog No.:BCN8630
CAS No.:145382-61-2
- Bacopaside V
Catalog No.:BCN8629
CAS No.:620592-16-7
- Saikosaponin G
Catalog No.:BCN8628
CAS No.:99365-19-2
- 17-Hydroxyisolathyrol
Catalog No.:BCN8627
CAS No.:93551-00-9
- Hypaconine
Catalog No.:BCN8640
CAS No.:63238-68-6
- Lancifodilactone C
Catalog No.:BCN8641
CAS No.:663176-26-9
- Myrrhone
Catalog No.:BCN8642
CAS No.:183551-83-9
- Caesappanin C
Catalog No.:BCN8643
CAS No.:1913319-59-1
- (1S,2S)-threo-Honokitriol
Catalog No.:BCN8644
CAS No.:1099687-80-5
- 1''-O-beta-D-glucopyranosylformoside
Catalog No.:BCN8645
CAS No.:148245-77-6
- 14,15beta-Dihydroxyklaineanone
Catalog No.:BCN8646
CAS No.:137359-82-1
- Nephthenol
Catalog No.:BCN8647
CAS No.:53915-41-6
- Bryodulcosigenin
Catalog No.:BCN8648
CAS No.:4965-97-3
- Euphorbia factor L7b
Catalog No.:BCN8649
CAS No.:93550-95-9
- Nortracheloside
Catalog No.:BCN8650
CAS No.:33464-78-7
- 1-Methyl-6-oxopyridine-3-carboxylic acid
Catalog No.:BCN8651
CAS No.:3719-45-7
Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity.[Pubmed:20022509]
Bioorg Med Chem. 2010 Jan 15;18(2):962-70.
Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10). The structures of the new compounds were determined by analysis of their spectroscopic data. Among the isolated compounds, 5'-formylglabridin (5), (2R,3R)-3,4',7-trihydroxy-3'-prenylflavane (7), echinatin, (3R)-2',3',7-trihydroxy-4'-methoxyisoflavan, kanzonol X, kanzonol W, shinpterocarpin, licoflavanone A, glabrol, shinflavanone, gancaonin L, and Glabrone all exhibited significant PPAR-gamma ligand-binding activity. The activity of these compounds at a sample concentration of 10microg/mL was three times more potent than that of 0.5microM troglitazone.
Computer-guided approach to access the anti-influenza activity of licorice constituents.[Pubmed:24313801]
J Nat Prod. 2014 Mar 28;77(3):563-70.
Neuraminidase (NA), a key enzyme in viral replication, is the first-line drug target to combat influenza. On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs). Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1 -benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), Glabrone (5), hispaglabridin B (6), licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results. Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening.
