FH1(BRD-K4477)Enhance cultured hepatocyte function CAS# 2719-05-3 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 2719-05-3 | SDF | Download SDF |
| PubChem ID | 94990 | Appearance | Powder |
| Formula | C17H18N2O2 | M.Wt | 282.34 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | NSC 12407, BRD-K4477 | ||
| Solubility | DMSO : 13 mg/mL (46.04 mM; Need ultrasonic and warming) | ||
| Chemical Name | N-[4-[(4-acetamidophenyl)methyl]phenyl]acetamide | ||
| SMILES | CC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)C | ||
| Standard InChIKey | OEXMNSOPAKOPEF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes; also promotes the maturation of iPSC-derived hepatocytes. |
FH1(BRD-K4477) Dilution Calculator
FH1(BRD-K4477) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5418 mL | 17.7091 mL | 35.4183 mL | 70.8366 mL | 88.5457 mL |
| 5 mM | 0.7084 mL | 3.5418 mL | 7.0837 mL | 14.1673 mL | 17.7091 mL |
| 10 mM | 0.3542 mL | 1.7709 mL | 3.5418 mL | 7.0837 mL | 8.8546 mL |
| 50 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.4167 mL | 1.7709 mL |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3542 mL | 0.7084 mL | 0.8855 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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FH1 is a small molecule that can enhance the functions of cultured hepatocytes [1].
FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].
References:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.
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Identification of small molecules for human hepatocyte expansion and iPS differentiation.[Pubmed:23728495]
Nat Chem Biol. 2013 Aug;9(8):514-20.
Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. However, this ability is lost ex vivo, and human hepatocyte sourcing has limited many fields of research for decades. Here we developed a high-throughput screening platform for primary human hepatocytes to identify small molecules in two different classes that can be used to generate renewable sources of functional human hepatocytes. The first class induced functional proliferation of primary human hepatocytes in vitro. The second class enhanced hepatocyte functions and promoted the differentiation of induced pluripotent stem cell-derived hepatocytes toward a more mature phenotype than what was previously obtainable. The identification of these small molecules can help address a major challenge affecting many facets of liver research and may lead to the development of new therapeutics for liver diseases.
