Erysotrine

CAS# 27740-43-8

Erysotrine

Catalog No. BCN5170----Order now to get a substantial discount!

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Quality Control of Erysotrine

Number of papers citing our products

Chemical structure

Erysotrine

3D structure

Chemical Properties of Erysotrine

Cas No. 27740-43-8 SDF Download SDF
PubChem ID 442219 Appearance Oil
Formula C19H23NO3 M.Wt 313.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,13bS)-2,11,12-trimethoxy-2,6,8,9-tetrahydro-1H-indolo[7a,1-a]isoquinoline
SMILES COC1CC23C(=CCN2CCC4=CC(=C(C=C34)OC)OC)C=C1
Standard InChIKey WXVSPYOOFCCEII-KXBFYZLASA-N
Standard InChI InChI=1S/C19H23NO3/c1-21-15-5-4-14-7-9-20-8-6-13-10-17(22-2)18(23-3)11-16(13)19(14,20)12-15/h4-5,7,10-11,15H,6,8-9,12H2,1-3H3/t15-,19-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Erysotrine

The barks of Aralia chinensis

Biological Activity of Erysotrine

Description1. Erysotrine does not show cytotoxic activity by itself, but exhibits significant cytotoxicity when combines with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). 2. (+)-Erysotrine shows potent dosedependant antifeedant activity at concentrations ≥100 ppm.
TargetsAChR

Erysotrine Dilution Calculator

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Erysotrine Molarity Calculator

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Preparing Stock Solutions of Erysotrine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1908 mL 15.9541 mL 31.9081 mL 63.8162 mL 79.7703 mL
5 mM 0.6382 mL 3.1908 mL 6.3816 mL 12.7632 mL 15.9541 mL
10 mM 0.3191 mL 1.5954 mL 3.1908 mL 6.3816 mL 7.977 mL
50 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.2763 mL 1.5954 mL
100 mM 0.0319 mL 0.1595 mL 0.3191 mL 0.6382 mL 0.7977 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Erysotrine

Anti-HIV-1 and cytotoxicity of the alkaloids of Erythrina abyssinica Lam. growing in Sudan.[Pubmed:21936641]

Nat Prod Res. 2012;26(17):1565-75.

Erythrina abyssinica Lam. is an important medicinal plant growing in Sudan; its seeds were investigated for the first time for their alkaloidal constituents and biological activity. The in vitro cytotoxicity of the crude alkaloidal fraction (CAF) against the cell lines HeLa, Hep-G2, HEP-2, HCT116, MCF-7 and HFB4 showed promising activity, with IC(5)(0) values of 13.8, 10.1, 8.16, 13.9, 11.4 and 12.2 microg mL(-)(1), respectively. Doxorubicin (positive control) showed in vitro cytotoxic activity with IC(5)(0) values 3.64, 4.57, 4.89, 3.74, 2.97 and 3.96 microg mL(-)(1), respectively. Bioassay-guided fractionation and isolation of the CAF led to the isolation of five Erythrina alkaloids, identified as erythraline, erysodine, Erysotrine, 8-oxoerythraline and 11-methoxyerysodine. These were evaluated for their in vitro cytotoxic activity against Hep-G2 which resulted in IC(5)(0) values 17.60, 11.80, 15.80, 3.89 and 11.40 microg mL(-)(1), respectively. Furthermore, in vitro cytotoxic activity against HEP-2 was evaluated, which resulted in IC(5)(0) values 15.90, 19.90, 21.60, 18.50 and 11.50 microg mL(-)(1), respectively. The CAF caused a reduction in the viability of mock-infected MT-4 cells with a CC(5)(0) of 53 microM and a 50% protection of MT-4 cells against HIV-1 induced cytopathogeneticy with a EC(5)(0) of >53 microM, compared with EFV as a positive control, which had a CC(5)(0) of 45 microM and an EC(5)(0) of 0.003 microM. We concluded that the isolated alkaloids were responsible for the anti-carcinogenic [corrected] actions of the plant extract previously reported in the literature.

TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.[Pubmed:19026536]

Bioorg Med Chem Lett. 2009 Jan 1;19(1):234-6.

A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2-7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.

Description

Erysotrine, isolated from seed pods of Erythrina latissima, shows antibacterial activities.

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