Dorzolamide HClCarbonic anhydrase inhibitor CAS# 130693-82-2 |
Related Products
- Tigecycline mesylate
Catalog No.:BCC4229
CAS No.:1135871-27-0
- Amphotericin B
Catalog No.:BCN2564
CAS No.:1397-89-3
- Nystatin (Fungicidin)
Catalog No.:BCC4813
CAS No.:1400-61-9
- Tigecycline hydrochloride
Catalog No.:BCC4228
CAS No.:197654-04-9
- Toyocamycin
Catalog No.:BCC8047
CAS No.:606-58-6
- Norfloxacin hydrochloride
Catalog No.:BCC4230
CAS No.:68077-27-0
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 130693-82-2 | SDF | Download SDF |
| PubChem ID | 6918132 | Appearance | Powder |
| Formula | C10H17ClN2O4S3 | M.Wt | 360.9 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | L671152 hydrochloride; MK507 hydrochloride | ||
| Solubility | DMSO : 100 mg/mL (277.09 mM; Need ultrasonic) H2O : 12.5 mg/mL (34.64 mM; Need ultrasonic) | ||
| Chemical Name | (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride | ||
| SMILES | CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl | ||
| Standard InChIKey | OSRUSFPMRGDLAG-QMGYSKNISA-N | ||
| Standard InChI | InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.
Target: carbonic anhydrase (CA)
Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour [1].
Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide hydrochloride 2%-timolol 0.5% combination eye drops, while the other experimental group was administered dorzolamide hydrochloride2% eye drops. Control groups had surgery without drug administration. Drug application was initiated either 2 weeks before surgery (Group A), from the day of surgery (Group B), 2 weeks after surgery (Group C), or 4 weeks after surgery (Group D). RGCs were labeled by intratectal Fluorogold injections and counted from flat-mount preparations, and IOP was measured using Tonopen. Both dorzolamide-timolol combination and dorzolamide hydrochloride, when applied topically, significantly reduced IOP and improved RGC densities in experimental eyes when compared to control eyes. Earlier initiation, as well as longer duration of drug application, resulted in higher RGC densities [2].
Clinical indications: Glaucoma; Ocular hypertension
FDA Approved Date: 1995
Toxicity: Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest References: | |||||
Dorzolamide HCl Dilution Calculator
Dorzolamide HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7709 mL | 13.8543 mL | 27.7085 mL | 55.417 mL | 69.2713 mL |
| 5 mM | 0.5542 mL | 2.7709 mL | 5.5417 mL | 11.0834 mL | 13.8543 mL |
| 10 mM | 0.2771 mL | 1.3854 mL | 2.7709 mL | 5.5417 mL | 6.9271 mL |
| 50 mM | 0.0554 mL | 0.2771 mL | 0.5542 mL | 1.1083 mL | 1.3854 mL |
| 100 mM | 0.0277 mL | 0.1385 mL | 0.2771 mL | 0.5542 mL | 0.6927 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Dorzolamide HCl is a carbonic anhydrase inhibitor.
Featured Products
- RP 001 hydrochloride
Catalog No.:BCC7905
CAS No.:1306761-53-4
- Ozanimod (RPC1063)
Catalog No.:BCC6533
CAS No.:1306760-87-1
- PD123319
Catalog No.:BCC5010
CAS No.:130663-39-7
- Bindarit
Catalog No.:BCC4965
CAS No.:130641-38-2
- N-(2-Hydroxyethyl)-3-(4-nitrophenyl)propylamine
Catalog No.:BCC9053
CAS No.:130634-09-2
- (R)-(+)-Corypalmine
Catalog No.:BCN2289
CAS No.:13063-54-2
- Nitidine chloride
Catalog No.:BCN4957
CAS No.:13063-04-2
- Yangambin
Catalog No.:BCN6706
CAS No.:13060-14-5
- alpha-Terthienylmethanol
Catalog No.:BCN6161
CAS No.:13059-93-3
- Mogroside III
Catalog No.:BCN3167
CAS No.:130567-83-8
- Liriope muscari baily Saponins
Catalog No.:BCN2817
CAS No.:130551-41-6
- Cannabisin A
Catalog No.:BCC8138
CAS No.:130508-46-2
New Products
- (R)-(+)-Propranolol hydrochloride
Catalog No.:BCC6810
CAS No.:13071-11-9
- SDZ WAG 994
Catalog No.:BCC7374
CAS No.:130714-47-5
- FR 122047 hydrochloride
Catalog No.:BCC7092
CAS No.:130717-51-0
- Decloxizine dihydrochloride
Catalog No.:BCC5549
CAS No.:13073-96-6
- m-CPP hydrochloride
Catalog No.:BCC5680
CAS No.:13078-15-4
- 6-O-benzoylgomisin O
Catalog No.:BCN3092
CAS No.:130783-32-3
- MDL-29951
Catalog No.:BCC4059
CAS No.:130798-51-5
- Sipatrigine
Catalog No.:BCC7847
CAS No.:130800-90-7
- Pseudolarifuroic acid
Catalog No.:BCN8048
CAS No.:130825-79-5
- 7-Oxohinokinin
Catalog No.:BCN6162
CAS No.:130837-92-2
- Scoparinol
Catalog No.:BCN6163
CAS No.:130838-00-5
- Decursinol angelate
Catalog No.:BCC9222
CAS No.:130848-06-5
Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods.[Pubmed:11929684]
J Pharm Biomed Anal. 2002 Apr 15;28(2):391-7.
Two-component mixtures of dorzolamide hydrochloride and timolol maleate were assayed by first derivative and ratio derivative spectrophotometric methods. The first method, derivative spectrophotometry, by the zero-crossing measurements, was used due to the drugs closely overlapping absorption spectra. Linear calibration graphs of first derivative values at 250.3 nm for dorzolamide hydrochloride and 315.8 nm for timolol maleate. The second method, is based on ratio first derivative spectrophotometry, the amplitudes in the first derivative of the ratio spectra at 242.9 and at 223.5 nm were selected to determine dorzolamide and timolol maleate in the binary mixture. Calibration graphs were established for 8.0-30.0 microg ml(-1) for dorzolamide hydrochloride and 3.0-24.6 microg ml(-1) for timolol maleate in binary mixture. Good linearity, precision and selectivity were found, and the proposed methods were applied successfully to the pharmaceutical dosage from containing the above-mentioned drug combination without any interference by the excipients. Vierordt's method was also developed for a comparison method.
Dorzolamide hydrochloride (L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.
Dorzolamide HCl,130693-82-2,L671152 hydrochloride; MK507 hydrochloride,Natural Products,Carbonic Anhydrase, buy Dorzolamide HCl , Dorzolamide HCl supplier , purchase Dorzolamide HCl , Dorzolamide HCl cost , Dorzolamide HCl manufacturer , order Dorzolamide HCl , high purity Dorzolamide HCl
