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Dehydroevodiamine hydrochloride

CAS# 111664-82-5

Dehydroevodiamine hydrochloride

Catalog No. BCN9178----Order now to get a substantial discount!

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Chemical structure

Dehydroevodiamine hydrochloride

3D structure

Chemical Properties of Dehydroevodiamine hydrochloride

Cas No. 111664-82-5 SDF Download SDF
PubChem ID 135393457 Appearance Yellow powder
Formula C19H16N3O M.Wt 302.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1,3,5,7,9,15,17,19-octaen-14-one;hydrochloride
SMILES CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3.Cl
Standard InChIKey SVOMSEHNGXLQRU-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H15N3O.ClH/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22;/h2-9H,10-11H2,1H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Dehydroevodiamine hydrochloride Dilution Calculator

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Dehydroevodiamine hydrochloride Molarity Calculator

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Preparing Stock Solutions of Dehydroevodiamine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3069 mL 16.5344 mL 33.0688 mL 66.1376 mL 82.672 mL
5 mM 0.6614 mL 3.3069 mL 6.6138 mL 13.2275 mL 16.5344 mL
10 mM 0.3307 mL 1.6534 mL 3.3069 mL 6.6138 mL 8.2672 mL
50 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.3228 mL 1.6534 mL
100 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.6614 mL 0.8267 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dehydroevodiamine hydrochloride

Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa.[Pubmed:8923803]

Planta Med. 1996 Oct;62(5):405-9.

To find a new compound with antiamnesic activity, we screened 29 natural products for their abilities to inhibit acetylcholinesterase and reverse scopolamine-induced amnesia. Among the plants tested Evodia rutaecarpa Bentham showed a strong inhibitory effect on acetylcholinesterase in vitro and an anti-amnesic effect in vivo. By sequential fractionation of E. rutaecarpa, the active component was finally identified as Dehydroevodiamine hydrochloride (DHED). DHED inhibited acetylcholinesterase activity in a dose-dependent and non-competitive manner. The IC50 value of DHED is 37.8 microM. A single administration of DHED to rats (6.25 mg/kg) significantly reversed the scopolamine-induced memory impairment in a passive avoidance test. The antiamnesic effect of DHED was more potent than that of tacrine which is the only drug for Alzheimer's disease approved by FDA. This potent antiamnesic effect of DHED was thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement. These results indicate that DHED has novel anti-cholinesterase and antiamnesic activities and might have therapeutic potential in various disorders including Alzheimer's disease.

Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa.[Pubmed:8201313]

J Nat Prod. 1994 Mar;57(3):387-9.

Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined. These results suggest that the compound selectively increases cerebral blood flow.

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