Cefoselis Sulfate

CAS# 122841-12-7

Cefoselis Sulfate

Catalog No. BCC4769----Order now to get a substantial discount!

Product Name & Size Price Stock
Cefoselis Sulfate:50mg $65.00 In stock
Cefoselis Sulfate:100mg $111.00 In stock
Cefoselis Sulfate:250mg $260.00 In stock
Cefoselis Sulfate:500mg $455.00 In stock
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Quality Control of Cefoselis Sulfate

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Chemical structure

Cefoselis Sulfate

3D structure

Chemical Properties of Cefoselis Sulfate

Cas No. 122841-12-7 SDF Download SDF
PubChem ID 9830519 Appearance Powder
Formula C19H24N8O10S3 M.Wt 620.64
Type of Compound N/A Storage Desiccate at -20°C
Synonyms FK-037
Solubility DMSO : 100 mg/mL (161.12 mM; Need ultrasonic)
H2O : 14.29 mg/mL (23.02 mM; Need ultrasonic)
Chemical Name (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[2-(2-hydroxyethyl)-3-iminopyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;sulfuric acid
SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O
Standard InChIKey LZOLCSVRFKCSEM-ZQCAECPKSA-N
Standard InChI InChI=1S/C19H22N8O6S2.H2O4S/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28;1-5(2,3)4/h2-3,8,13,17,20,28H,4-7H2,1H3,(H2,21,22)(H,23,29)(H,31,32);(H2,1,2,3,4)/b20-11?,24-12-;/t13-,17-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Cefoselis Sulfate

DescriptionCefoselis is a widely used beta-lactam antibiotic. Target: Antibacterial Cefoselis, a new parenteral cephalosporin, was active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. The activity of Cefoselis was similar to that of cefpirome and cefepime and generally superior to that of ceftazidime. Cefoselis showed potent antibacterial activity against Hemophilus influenzae and Moraxella catarrhalis.Cefoselis was highly active against MSSA and MSCNS. Cefoselis was poor in the activity against MRSA,MRCNS,PRSP and Enterococcus faecalis,and no activity for Enterococcus faecium.

References:
[1]. ZHU, D., et al., In vitro activities of cefoselis compared to β-lactams and other antibacterial agents aganst gram-positive and gram-negative clinical isolates. Chinese Journal of Infection and Chemotherapy, 2011. 4: p. 002. [2]. King, A., L. Bethune, and I. Phillips, The Comparative In Vitro Activity of FK-037 (Cefoselis), a New Broad-Spectrum Cephalosporin. Clin Microbiol Infect, 1995. 1(1): p. 13-17.

Cefoselis Sulfate Dilution Calculator

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Cefoselis Sulfate Molarity Calculator

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Preparing Stock Solutions of Cefoselis Sulfate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6112 mL 8.0562 mL 16.1124 mL 32.2248 mL 40.281 mL
5 mM 0.3222 mL 1.6112 mL 3.2225 mL 6.445 mL 8.0562 mL
10 mM 0.1611 mL 0.8056 mL 1.6112 mL 3.2225 mL 4.0281 mL
50 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.6445 mL 0.8056 mL
100 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.3222 mL 0.4028 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Cefoselis Sulfate

Cefoselis is a widely used beta-lactam antibiotic.

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References on Cefoselis Sulfate

Stability studies of cefoselis sulfate in the solid state.[Pubmed:26073113]

J Pharm Biomed Anal. 2015 Oct 10;114:222-6.

The process of degradation was studied by using an HPLC-DAD method. Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of Cefoselis Sulfate was investigated. In the solid state at increased RH the degradation of Cefoselis Sulfate was an autocatalytic reaction of the first order with respect to substrate concentration while in dry air was first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.

Description

Cefoselis sulfate is a widely used beta-lactam antibiotic.

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