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BIX 01294 Trihydrochloride

CAS# 1392399-03-9

BIX 01294 Trihydrochloride

Catalog No. BCN9834----Order now to get a substantial discount!

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BIX 01294 Trihydrochloride: 5mg Please Inquire In Stock
BIX 01294 Trihydrochloride: 10mg Please Inquire In Stock
BIX 01294 Trihydrochloride: 20mg Please Inquire Please Inquire
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Quality Control of BIX 01294 Trihydrochloride

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Chemical structure

BIX 01294 Trihydrochloride

3D structure

Chemical Properties of BIX 01294 Trihydrochloride

Cas No. 1392399-03-9 SDF Download SDF
PubChem ID 46945860 Appearance Powder
Formula C28H38N6O2.3HCl M.Wt 600.02
Type of Compound Inhibitors Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine;trihydrochloride
SMILES CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl
Standard InChIKey FMURUEPQXKJIPS-UHFFFAOYSA-N
Standard InChI InChI=1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

BIX 01294 Trihydrochloride Dilution Calculator

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BIX 01294 Trihydrochloride Molarity Calculator

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Preparing Stock Solutions of BIX 01294 Trihydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6666 mL 8.3331 mL 16.6661 mL 33.3322 mL 41.6653 mL
5 mM 0.3333 mL 1.6666 mL 3.3332 mL 6.6664 mL 8.3331 mL
10 mM 0.1667 mL 0.8333 mL 1.6666 mL 3.3332 mL 4.1665 mL
50 mM 0.0333 mL 0.1667 mL 0.3333 mL 0.6666 mL 0.8333 mL
100 mM 0.0167 mL 0.0833 mL 0.1667 mL 0.3333 mL 0.4167 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on BIX 01294 Trihydrochloride

G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress.[Pubmed:32256958]

Oxid Med Cell Longev. 2020 Mar 12;2020:6983268.

Background: G9a, a well-known methyltransferase, plays a vital role in biological processes. However, its role in corneal neovascularization (CoNV) remains unclear. Methods. In vitro and in vivo models were assessed in hypoxia-stimulated angiogenesis and in a mouse model of alkali burn-induced CoNV. Human umbilical vein endothelial cells (HUVECs) were cultured under hypoxic conditions and different reoxygenation times to identify the molecular mechanisms involved in this process. Results: In this study, we found that G9a was positively related to corneal alkali burn-induced injury. Inhibition of G9a with BIX 01294 (BIX) alleviated corneal injury, including oxidative stress and neovascularization in vivo models were assessed in hypoxia-stimulated angiogenesis and in a mouse model of alkali burn-induced CoNV. Human umbilical vein endothelial cells (HUVECs) were cultured under hypoxic conditions and different reoxygenation times to identify the molecular mechanisms involved in this process.

H3K9 Demethylation-Induced R-Loop Accumulation Is Linked to Disorganized Nucleoli.[Pubmed:32117455]

Front Genet. 2020 Feb 6;11:43.

The nucleolar structure and integrity are important for a range of cellular functions of the nucleoli. It has been shown that cells lacking histone H3 Lysine 9 (H3K9) methylation form fragmented nucleoli. However, the molecular mechanism involved remains poorly understood. Here, we present evidence suggesting that loss of H3K9 dimethylation (H3K9me2) triggers R-loop accumulation at the rDNA locus, which further leads to the multilobed nucleoli. We reveal that suppression of H3K9 methyltransferase G9a by the inhibitor BIX 01294 causes R-loop accumulation at the rDNA region as well as inducing formation of multiple nucleoli. SiRNA-mediated knockdown of RNase H1 which can hydrolyze the RNA chain in R-loops causes an increase in R-loop formation, which in turn results in multiple nucleoli in one nucleus, whereas H3K9me2 levels are not affected by R-loop accumulation. Inhibition of RNA polymerase I transcription elongation by small molecule inhibitors induces a substantial decrease in H3K9me2 levels, accumulation of R-loops at rDNA sites, and nucleolus fragmentation. These results provide a mechanistic insight into the role of H3K9me2 in the structural integrity and organization of nucleoli via regulating R-loop accumulation.

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