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3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

CAS# 168293-14-9

3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

Catalog No. BCN1531----Order now to get a substantial discount!

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3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid: 5mg $173 In Stock
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Quality Control of 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

Number of papers citing our products

Chemical structure

3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

3D structure

Chemical Properties of 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

Cas No. 168293-14-9 SDF Download SDF
PubChem ID 15226714 Appearance Powder
Formula C32H48O5 M.Wt 512.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3-acetyloxy-16-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid
SMILES CC(=CCCC(C1C(CC2(C1(CC=C3C2=CCC4C3(CCC(C4(C)C)OC(=O)C)C)C)C)O)C(=O)O)C
Standard InChIKey DLBLMTCYISHWGP-KOCSMGCBSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

The sclerotium of Poria cocos(Schw.) Wolf

Biological Activity of 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

Description1. 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
TargetsNO | NOS | PGE | COX

3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid Dilution Calculator

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3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid Molarity Calculator

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Preparing Stock Solutions of 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9505 mL 9.7523 mL 19.5046 mL 39.0092 mL 48.7615 mL
5 mM 0.3901 mL 1.9505 mL 3.9009 mL 7.8018 mL 9.7523 mL
10 mM 0.195 mL 0.9752 mL 1.9505 mL 3.9009 mL 4.8761 mL
50 mM 0.039 mL 0.195 mL 0.3901 mL 0.7802 mL 0.9752 mL
100 mM 0.0195 mL 0.0975 mL 0.195 mL 0.3901 mL 0.4876 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.[Pubmed:27912907]

Bioorg Chem. 2017 Feb;70:94-99.

Poria cocos Wolf (Polyporaceae) has been used as a medicinal fungus to treat various diseases since ancient times. This study aimed to investigate the anti-inflammatory chemical constituents of the sclerotia of P. cocos. Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-acetyl-16alpha-hydroxydehydrotrametenolic acid (2), polyporenic acid C (3), 3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8). The structures of the isolated compounds were determined by spectroscopic analysis, including (1)H and (13)C NMR spectra, and LC/MS analysis. The anti-inflammatory activities of the isolates were evaluated by estimating their effect on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated Raw264.7 as well as on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Compounds 1-5 inhibited NO production and iNOS expression in LPS-stimulated Raw264.7 cells. Among them, compound 1 exerted the highest anti-inhibitory activity and reduced PGE2 levels via downregulation of COX-2 protein expression. The findings of this study provide experimental evidence that the sclerotia of P. cocos are a potential source of natural anti-inflammatory agents for use in pharmaceuticals and functional foods. Furthermore, the most active compound 1, seco-lanostane triterpenoid, could be a promising lead compound for the development of novel anti-inflammatory agents.

One-step separation of nine structural analogues from Poria cocos (Schw.) Wolf. via tandem high-speed counter-current chromatography.[Pubmed:26435185]

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 1;1004:10-6.

A novel one-step separation strategy-tandem high-speed counter-current chromatography (HSCCC) was developed with a six-port valve serving as the switch interface. Nine structural analogues including three isomers were successfully isolated from Poria cocos (Schw.) Wolf. by one step. Compared with conventional HSCCC, peak resolution of target compounds was effectively improved in tandem one. Purities of isolated compounds were all over 90% as determined by HPLC. Their structures were then identified via UV, MS and (1)H NMR, and eventually assigned as poricoic acid B (1), poricoic acid A (2), 3beta,16alpha-dihydroxylanosta-7, 9(11), 24-trien-21-oic acid (3), dehydrotumulosic acid (4), polyporenic acid C (5), 3-epi-dehydrotumulosic acid (6), 3-o-acetyl-16alpha-hydroxydehydrotrametenolic acid (7), dehydropachymic acid (8) and dehydrotrametenolic acid (9) respectively. The results indicated that tandem HSCCC can effectively improve peak resolution of target compounds, and can be a good candidate for HSCCC separation of structural analogues.

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