2beta-AcetoxyferruginolCAS# 1206461-56-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1206461-56-4 | SDF | Download SDF |
| PubChem ID | 131676089 | Appearance | Powder |
| Formula | C22H32O3 | M.Wt | 344.49 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(3R,4aS,10aS)-6-hydroxy-1,1,4a-trimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-3-yl] acetate | ||
| SMILES | CC(C)C1=C(C=C2C(=C1)CCC3C2(CC(CC3(C)C)OC(=O)C)C)O | ||
| Standard InChIKey | ZTRHRDVSZYCIJZ-QGCDCVKKSA-N | ||
| Standard InChI | InChI=1S/C22H32O3/c1-13(2)17-9-15-7-8-20-21(4,5)11-16(25-14(3)23)12-22(20,6)18(15)10-19(17)24/h9-10,13,16,20,24H,7-8,11-12H2,1-6H3/t16-,20+,22-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 2beta-Acetoxyferruginol showed activity against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 ug/ml. |
| Targets | Antifection |
2beta-Acetoxyferruginol Dilution Calculator
2beta-Acetoxyferruginol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9028 mL | 14.5142 mL | 29.0284 mL | 58.0568 mL | 72.571 mL |
| 5 mM | 0.5806 mL | 2.9028 mL | 5.8057 mL | 11.6114 mL | 14.5142 mL |
| 10 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL | 5.8057 mL | 7.2571 mL |
| 50 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.1611 mL | 1.4514 mL |
| 100 mM | 0.029 mL | 0.1451 mL | 0.2903 mL | 0.5806 mL | 0.7257 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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2β-Acetoxyferruginol—A new antibacterial abietane diterpene from the bark of Prumnopitys andina
Phytochemistry Letters, 2008, 1(1):49-53.
As part of an on-going project to isolate antibacterial compounds from rare conifer species, a new abietane diterpene, 2beta-Acetoxyferruginol was isolated from the stem bark of Prumnopitys andina. Molecular modelling studies were conducted to explain some of the NOEs observed in the A-ring of this compound and to support assignment of relative stereochemistry. This new compound had antibacterial activity at 8 μg/ml against two effluxing strains of Staphylococcus aureus, but interestingly was inactive at 128 μg/ml against a wild-type strain and against a methicillin-resistant (MRSA) clinical isolate. We have previously demonstrated that ferruginol is active against these four S. aureus stains and therefore the results indicate that the presence of the acetoxy group has a detrimental effect on antibacterial activity against certain strains. 2beta-Acetoxyferruginol was also assayed against Propionibacterium acnes and was active at 4 μg/ml.Graphical abstractA new antibacterial abietane diterpene, 2beta-Acetoxyferruginol (1) was isolated from the stem bark of Prumnopitys andina and its structure was determined by spectral means. Activity was assessed against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 μg/ml.
