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2-Hydroxy-3-methoxybenzoic acid glucose ester

CAS# 172377-87-6

2-Hydroxy-3-methoxybenzoic acid glucose ester

Catalog No. BCN7407----Order now to get a substantial discount!

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2-Hydroxy-3-methoxybenzoic acid glucose ester: 5mg $615 In Stock
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2-Hydroxy-3-methoxybenzoic acid glucose ester: 1000mg Please Inquire Please Inquire

Quality Control of 2-Hydroxy-3-methoxybenzoic acid glucose ester

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Chemical structure

2-Hydroxy-3-methoxybenzoic acid glucose ester

3D structure

Chemical Properties of 2-Hydroxy-3-methoxybenzoic acid glucose ester

Cas No. 172377-87-6 SDF Download SDF
PubChem ID 101687175 Appearance Powder
Formula C14H18O9 M.Wt 330.28
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] 2-hydroxy-3-methoxybenzoate
SMILES COC1=CC=CC(=C1O)C(=O)OC2C(C(C(C(O2)CO)O)O)O
Standard InChIKey AKQPDLWSZUWOPL-CGUBKOMSSA-N
Standard InChI InChI=1S/C14H18O9/c1-21-7-4-2-3-6(9(7)16)13(20)23-14-12(19)11(18)10(17)8(5-15)22-14/h2-4,8,10-12,14-19H,5H2,1H3/t8-,10-,11+,12-,14+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2-Hydroxy-3-methoxybenzoic acid glucose ester

The whole plants of Gentiana scabra.

Biological Activity of 2-Hydroxy-3-methoxybenzoic acid glucose ester

Description1. 2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
TargetsPAFR

2-Hydroxy-3-methoxybenzoic acid glucose ester Dilution Calculator

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2-Hydroxy-3-methoxybenzoic acid glucose ester Molarity Calculator

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Preparing Stock Solutions of 2-Hydroxy-3-methoxybenzoic acid glucose ester

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0277 mL 15.1387 mL 30.2773 mL 60.5547 mL 75.6934 mL
5 mM 0.6055 mL 3.0277 mL 6.0555 mL 12.1109 mL 15.1387 mL
10 mM 0.3028 mL 1.5139 mL 3.0277 mL 6.0555 mL 7.5693 mL
50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.2111 mL 1.5139 mL
100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-Hydroxy-3-methoxybenzoic acid glucose ester

PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra.[Pubmed:9875472]

Arch Pharm Res. 1998 Aug;21(4):436-9.

In order to find out anti-platelet activating factor (PAF) from natural resources, Korean medicinal plants used for the treatments of peripheral circulation disorders were tested for their possible protective effects on PAF-induced anaphylactic shock. From the above screening, the methanol extract of Gentiana scabra showed a potent antagonistic activity against PAF. Water suspension of the extract was partitioned with CH2Cl2 and EtOAc, successively. The EtOAc fraction which showed the highest activity was chromatographed on silica gel to yield 6 fractions. From the fraction which showed higher PAF-antagonistic activity than the other fractions, compound 1 was isolated by recrystallization. On the basis of spectral data, compound 1 was identified as 2-Hydroxy-3-methoxybenzoic acid glucose ester. The compound prevented the mice from the PAF-induced death at a dose of 300 micrograms/mouse.

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