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Home >> Research Area >>Nature Products >> 16-Kaurene-2,6,15-triol


Catalog No. BCN5706
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20mg $298 In stock
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Quality Control of 16-Kaurene-2,6,15-triol

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Chemical Properties of 16-Kaurene-2,6,15-triol

Cas No. 53452-32-7 SDF Download SDF
Type of Compound Diterpenoids Appearance Powder
Formula C20H32O3 M.Wt 320.5
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 16-Kaurene-2,6,15-triol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1201 mL 15.6006 mL 31.2012 mL 62.4025 mL 78.0031 mL
5 mM 0.624 mL 3.1201 mL 6.2402 mL 12.4805 mL 15.6006 mL
10 mM 0.312 mL 1.5601 mL 3.1201 mL 6.2402 mL 7.8003 mL
50 mM 0.0624 mL 0.312 mL 0.624 mL 1.248 mL 1.5601 mL
100 mM 0.0312 mL 0.156 mL 0.312 mL 0.624 mL 0.78 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 16-Kaurene-2,6,15-triol

This product is isolated and purified from the herbs of Rabdosia amethystoides

References on 16-Kaurene-2,6,15-triol

Intelligence and all-cause mortality in the 6-Day Sample of the Scottish Mental Survey 1947 and their siblings: testing the contribution of family background.[Pubmed: 29025063]

Higher early-life intelligence is associated with a reduced risk of mortality in adulthood, though this association is apparently hardly attenuated when accounting for early-life socio-economic status (SES). However, the use of proxy measures of SES means that residual confounding may underestimate this attenuation. In the present study, the potential confounding effect of early-life SES was instead accounted for by examining the intelligence-mortality association within families.

Efficient synthesis of 1,9-substituted benzo[h][1,6]naphthyridin-2(1H)-ones and evaluation of their Plasmodium falciparum gametocytocidal activities.[Pubmed: 29024590]

A novel three-component, two-step, one-pot nucleophilic aromatic substitution (SNAr)-intramolecular cyclization-Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). Based on the new efficiently convergent synthetic route, a library of Torin analogs was synthesized. The antimalarial activities of these compounds were evaluated against asexual parasites using a growth inhibition assay and gametocytes using a viability assay.

Inflammation and cardio-renal interactions in heart failure: a potential role for interleukin-6.[Pubmed: 29024287]

Functional interleukin-6 receptor-α is located to tanycytes at the base of the third ventricle.[Pubmed: 29024103]

Interleukin-6 (IL-6) - /- mice develop mature onset obesity, while intracerebroventricular (ICV) injection of IL-6 decreases obesity in rodents. Moreover, levels of IL-6 in cerebrospinal fluid (CSF) have been reported to be inversely correlated with obesity in humans. Tanycytes lining the base of the 3rd ventricle in the hypothalamus have recently been reported to be of importance for metabolism. In the present study, we investigated whether tanycytes could respond to IL-6 in the CSF. With immunohistochemistry using a well characterized antibody directed against the ligand binding receptor for IL-6, IL-6 receptor α (IL-6Rα), it was found that tanycytes, identified by the two markers vimentin and dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), contained IL-6Rα. There were fewer IL-6Rα on another type of ventricle-lining cells, ependymal cells, identified by the marker glucose transporter-1 (GLUT-1). To ascertain that the immunoreactive IL-6Rα were responsive to IL-6, we injected IL-6 ICV. This treatment increased immunoreactive phosphorylated STAT-3 (pSTAT-3) in tanycytes after 5 min and in cells in the medial part of the arcuate nucleus (ARC) after 5 and 15 min. ICV injection of leptin exerted similar effects. As expected, intraperitoneal (i.p.) injection of leptin also induced pSTAT-3 staining in the hypothalamus, while IP IL-6 injection had little effect on this parameter. ICV or IP injection of vehicle only had no effect on pSTAT3-immunoreactivity. In summary, there are functional IL-6Rα on tanycytes at the bottom of the third ventricle (3V), in line with the possibility that ventricular administration of IL-6 decreases obesity in mice via an effect on this cell type. This article is protected by copyright. All rights reserved.


16-Kaurene-2,6,15-triol ,53452-32-7,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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