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15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

Catalog No. BCN1637
Size Price Stock
20mg $298 In stock
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Quality Control of 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

Chemical structure

15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

Biological Activity of 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

Reference standards.

15-Nor-14-oxolabda-8(17),12-dien-18-oic acid Dilution Calculator

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Chemical Properties of 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

Cas No. 1039673-32-9 SDF Download SDF
Type of Compound Diterpenoids Appearance Powder
Formula C19H28O3 M.Wt 304.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2852 mL 16.4258 mL 32.8515 mL 65.703 mL 82.1288 mL
5 mM 0.657 mL 3.2852 mL 6.5703 mL 13.1406 mL 16.4258 mL
10 mM 0.3285 mL 1.6426 mL 3.2852 mL 6.5703 mL 8.2129 mL
50 mM 0.0657 mL 0.3285 mL 0.657 mL 1.3141 mL 1.6426 mL
100 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.657 mL 0.8213 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

This product is isolated and purified from the barks of Pinus yunnanensis

References on 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

A new labdane diterpenoid with anti-inflammatory activity from Thuja orientalis.[Pubmed: 23422333]


ETHONOPHARMACOLOGICAL RELEVANCE: Thuja orientalis (L) ENDL (Cupressaceae) is an evergreen arbor that is distributed throughout Northeast Asia. This plant has been used as a traditional medicine for the treatment of various inflammatory diseases such as dermatitis, gout and chronic tracheitis.



Labdane-type diterpenes active against acne from pine cones (Pinus densiflora).[Pubmed: 18484541]


Bioassay-guided extraction and fractionation of the aqueous methanolic extract of the cones of Pinus densiflora (Pinaceae) afforded one new labdane-type diterpene aldehyde, 15-nor-14-oxolabda-8(17),12 E-diene-18-oic acid, along with eight known diterpenes. Their structures were elucidated using spectroscopic methods as well as by comparison with previously reported data. The isolates showed antibacterial (Propionibacterium acnes) and antifungal activities.



Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.[Pubmed: 12502340]


A new nor-labdane-type diterpene, 15-nor-labda-8(17),12E-dien-13,19-dienoic acid (1), along with five known diterpenes, 15-nor-14-oxolabda-8(17),12E-dien-19-oic acid (2), trans-communic acid (3), sandaracopimaric acid (4), dehydroabietic acid (5), and abieta-8,11,13-triene-15,18-diol (6), was isolated from the cones of Pinus luchuensis. The structure of 1 was established by chemical and spectroscopic methods. Among these isolates, compounds 2, 4, and 6 showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.



Labdane-type diterpenes and a nordrimane-type sesquiterpene from the stem bark of Thuja standishii.[Pubmed: 11076557]


Two new labdane-type diterpene aldehydes, 15-oxolabda-8(17),11(Z), 13(E)-trien-19-oic acid (1) and 15-oxolabda-8(17),11(Z), 13(Z)-trien-19-oic acid (2), and a new nordrimane-type sesquiterpene, 12-oxo-11-nordrim-8-en-14-oic acid (3), along with a known diterpene, 15-nor-14-oxolabda-8(17),12(E)-dien-19-oic acid (4), were isolated from the stem bark of Thuja standishii. The structures of 1-3 were established by spectroscopic methods.



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