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Catalog No. BCN3267
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20mg $298 In stock
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Quality Control of 10-Shogaol

Chemical structure


Biological Activity of 10-Shogaol

1. 10-Shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
2. 8- and 10-Shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells.

10-Shogaol Dilution Calculator

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10-Shogaol Molarity Calculator



Chemical Properties of 10-Shogaol

Cas No. 36752-54-2 SDF Download SDF
Chemical Name (E)-1-(4-hydroxy-3-methoxyphenyl)tetradec-4-en-3-one
Standard InChI InChI=1S/C21H32O3/c1-3-4-5-6-7-8-9-10-11-12-19(22)15-13-18-14-16-20(23)21(17-18)24-2/h11-12,14,16-17,23H,3-10,13,15H2,1-2H3/b12-11+
Type of Compound Phenols Appearance Oil
Formula C21H32O3 M.Wt 332.5
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 10-Shogaol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0075 mL 15.0376 mL 30.0752 mL 60.1504 mL 75.188 mL
5 mM 0.6015 mL 3.0075 mL 6.015 mL 12.0301 mL 15.0376 mL
10 mM 0.3008 mL 1.5038 mL 3.0075 mL 6.015 mL 7.5188 mL
50 mM 0.0602 mL 0.3008 mL 0.6015 mL 1.203 mL 1.5038 mL
100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6015 mL 0.7519 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 10-Shogaol

This product is isolated and purified from the rhizomes of Zingber officinale Rosc.

References on 10-Shogaol

10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer.[Pubmed: 22408422]

In this work, one of Zingiber officinale components, 10-Shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-Shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-Shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.

Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.[Pubmed: 24786146]

Shogaols, the major constituents of thermally processed ginger, have been proven to be highly effective anticancer agents. Our group has identified cysteine-conjugated shogaols (M2, M2', and M2″) as the major metabolites of [6]-, [8]-, and 10-Shogaol in human and found that M2 is a carrier of its parent molecule [6]-shogaol in cancer cells and in mice, while being less toxic to normal colon fibroblast cells. The objectives of this study are to determine whether M2' and M2″ behave in a similar manner to M2, in both metabolism and efficacy as anticancer agents, and to further explore the biological pro-apoptotic mechanisms of the cysteine-conjugated shogaols against human colon cancer cells HCT-116 and HT-29. Our results show that [8]- and 10-Shogaol have similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells. A brief screen of the markers attenuated by the proapoptotic activity of M2 revealed similar results for [8]- and 10-Shogaol and their respective cysteine-conjugated metabolites M2' and M2″. This study highlights the cysteine-conjugated metabolites of shogaols as novel dietary colon cancer preventive agents.


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