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Catalog No. BCN2973
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20mg $298 In stock
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Quality Control of 1-Octacosanol

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Chemical Properties of 1-Octacosanol

Cas No. 557-61-9 SDF Download SDF
Chemical Name Octacosan-1-ol
Standard InChI InChI=1S/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3
Type of Compound Miscellaneous Appearance Oil
Formula C18H38O M.Wt 270.5
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1-Octacosanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6969 mL 18.4843 mL 36.9686 mL 73.9372 mL 92.4214 mL
5 mM 0.7394 mL 3.6969 mL 7.3937 mL 14.7874 mL 18.4843 mL
10 mM 0.3697 mL 1.8484 mL 3.6969 mL 7.3937 mL 9.2421 mL
50 mM 0.0739 mL 0.3697 mL 0.7394 mL 1.4787 mL 1.8484 mL
100 mM 0.037 mL 0.1848 mL 0.3697 mL 0.7394 mL 0.9242 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1-Octacosanol

This product is isolated and purified from the herbs of Triticum aestivum L.

References on 1-Octacosanol

Effect of water, metallic ions, fatty acid and temperature on oxidative stability of 1-octacosanol from sugarcane rind.[Pubmed: 25842324]

The chemical composition and selected physical parameters of crude 1-octacosanol (1-OC) extracted from sugarcane rind have been determined. GC-MS results exhibited that 1-OC sample was primarily composed of 1-OC (45.17%), 1-docosene (12.04%), 1-triacontanol (0.23%), 1-heneicosanol (0.33%), 1-tetracosanal (0.28%), campesterol (4.5%), stigmasterol (9.12%) and β-sitosterol (8.23%). The linoleic acid had important effects on physical and chemical properties of 1-OC sample, as it notably changed the melting point and the onset oxidation temperature To of 1-OC sample from 83.75 ± 0.35 °C to 63.25 ± 0.35 °C and 245.64 ± 2.04 °C to 160.03 ± 0.01 °C, respectively. It was also proved that the oxidation reactions were significantly different at different temperature levels. 1-OC was stable up to 245.64 ± 2.04 °C. However, when the temperature continued to rise, 1-OC and its oxidation products started to be oxidized. Therefore, attention should be paid to the quality of 1-OC during the preparation of food and to minimize the undesirable breakdown products.

High-performance thin-layer chromatography for quantification of 1-octacosanol in Antarctic krill (Euphausia superba Dana).[Pubmed: 25146498]

1-Octacosanol is a straight-chain aliphatic 28-carbon fatty alcohol with well-known anti-fatigue function. In this study, 1-octacosanol was extracted from Antarctic krill for the first time. Separation of 1-octacosanol was achieved using high-performance thin-layer chromatography (TLC) with a mobile phase consisting of petroleum ether/ethyl acetate/toluene (4 : 1 : 0.05, v/v/v) on precoated silica gel GF254 high-performance TLC plates. The separated 1-octacosanol was quantified using spectrodensitometry with distilled water/bromothymol blue/sodium hydroxide (100 : 0.1 : 0.7, v/w/w) as a chromogenic system. The high-performance TLC method was validated with respect to specificity, linearity, intra- and interplate variation. The stability of the 1-octacosanol-chromogen complex and recovery of 1-octacosanol were also evaluated. Containing ~10.6 µg/mg 1-octacosanol, Antarctic krill is potentially a rich and renewable source of 1-octacosanol.

Synthesis of 1-octacosanol and GC-C-IRMS discrimination of samples from different origin.[Pubmed: 20306365]

Lately, long-chain primary alcohols have been investigated in depth on account of their biological activities. In particular, 1-octacosanol (C(28)H(57)OH), the main component of policosanol, the hypolipidaemic fatty alcohol mixture obtained from sugar cane wax, has been the subject of a multitude of pharmacological studies. The aim of this work was to search a convenient synthetic protocol for the preparation of 1-octacosanol in a gram scale. The key step was a Wittig reaction between the octadecyltriphenylphosphonium ylide and the methyl 10-oxodecanoate. Some steps were further improved by power ultrasound and microwave irradiation, either alone or in combination. Our methodology is suitable for a rapid generation of homologues by varying the chain length in the alkyl halide. Due to the high commercial value, a series of 1-octacosanol samples, either isolated from natural sources or from synthesis (different origin and suppliers), were analysed by gas chromatography-combustion-isotopic ratio mass spectrometry (GC-C-IRMS) and according to the carbon isotopic content, classified on the basis of their origin.

Trace quantification of 1-octacosanol and 1-triacontanol and their main metabolites in plasma by liquid-liquid extraction coupled with gas chromatography-mass spectrometry.[Pubmed: 19931494]

A method for the simultaneous determination of 1-octacosanol and 1-triacontanol and their main metabolites in rat plasma was developed. The procedure involved ethanolic NaOH saponification of the sample, acidification, liquid-liquid extraction, and derivatization of the analytes to its trimethylsilylether/ester, followed analysis by gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring (SIM) mode. Quantification was performed by the internal standard method using betulin. The method had a good linearity over the range 8.4-540ng/ml (r>or=0.998) and showed an excellent intra-day (R.S.D.=0.59-3.06%) and inter-day (R.S.D.=2.99-5.22%) precision according to the acceptance criteria. The detection limits ranged between 1.32 and 3.47ng/ml. The method was applied successfully to study the total plasmatic concentration of 1-octacosanol, octacosanoic acid, 1-triacontanol, and triacontanoic acid, after an oral dose of policosanols mixture, using plasma samples of 100microl.


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