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Catalog No. BCN1032
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20mg $148 In stock
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Quality Control of 1-Deoxynojirimycin

Chemical structure


Biological Activity of 1-Deoxynojirimycin

Inhibitor of glucosidase I (Ki = 2.1 mM) and II (Ki = 7 mM).

1-Deoxynojirimycin Dilution Calculator

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1-Deoxynojirimycin Molarity Calculator



Chemical Properties of 1-Deoxynojirimycin

Cas No. 19130-96-2 SDF Download SDF
Chemical Name (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol
SMILES C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
Standard InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
Type of Compound Miscellaneous Appearance Powder
Formula C6H13NO4 M.Wt 163.17
Solubility Soluble to 100 mM in water
Storage Store at +4°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1-Deoxynojirimycin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.1286 mL 30.6429 mL 61.2858 mL 122.5716 mL 153.2144 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL 24.5143 mL 30.6429 mL
10 mM 0.6129 mL 3.0643 mL 6.1286 mL 12.2572 mL 15.3214 mL
50 mM 0.1226 mL 0.6129 mL 1.2257 mL 2.4514 mL 3.0643 mL
100 mM 0.0613 mL 0.3064 mL 0.6129 mL 1.2257 mL 1.5321 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1-Deoxynojirimycin

This product is isolated and purified from the root barks of Morus alba L.

References on 1-Deoxynojirimycin

Design and application of a novel high-throughput screening technique for 1-deoxynojirimycin.[Pubmed: 25708517]

High-throughput screening techniques for small molecules can find intensive applications in the studies of biosynthesis of these molecules. A sensitive, rapid and cost-effective technique that allows high-throughput screening of endogenous production of the natural iminosugar 1-Deoxynojirimycin (1-DNJ), an α-glucosidase inhibitor relevant to the pharmaceutical industry, was developed in this study, based on the inhibitory effects of 1-Deoxynojirimycin on the activity of the β-glycosidase LacS from Sulfolobus solfataricus. This technique has been demonstrated effective in engineering both the key enzyme and the expression levels of enzymes in the 1-Deoxynojirimycin Jbiosynthetic pathway from Bacillus atrophaeus cloned in E. coli. Higher biosynthetic efficiency was achieved using directed evolution strategies.

1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice.[Pubmed: 25445511]

The aim of this study was to determine whether 1-Deoxynojirimycin (DNJ) isolated from Bacillus subtilis MORI beneficially influences lipid metabolism and mitochondrial function in the liver of mice fed a high-fat diet in addition to the anti-obesity properties of 1-Deoxynojirimycin. Male C57BL/6 mice (n = 29; 5 weeks old) were randomly assigned to three groups: normal control diet (CTL, n = 10), high-fat diet (HF, n = 10), and high-fat diet supplemented with 1-Deoxynojirimycin (DNJ, n = 9). After 12 weeks, the HF group exhibited higher overall weight gain, of the liver, and of various fat pads than the CTL and 1-Deoxynojirimycin groups did. The HF group also showed greater expression of C/EBPα and CD36 mRNA in the liver than that in the CTL and/or 1-Deoxynojirimycin groups. In addition, mRNA expressions of AAC and FAS were lower, while mRNA expression of PGC-1β was higher in the liver of the 1-Deoxynojirimycin group than that of the HF group. The hepatic expression of p-AMPK/AMPK was higher in the 1-Deoxynojirimycin group than in the HF group. This study provides novel insight into the protective effect of 1-Deoxynojirimycin supplementation against obesity-induced hepatic lipid abnormalities and mitochondrial dysfunction.

A Comparison of Food-grade Folium mori ( Sāng Yè) Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats.[Pubmed: 25161921]

Folium mori ( Sāng Yè, leaf of Morus alba L.; FM) is known to possess hypoglycemic effects, and 1-Deoxynojirimycin (1-DNJ) has been proposed as an important functional compound in FM. However, the hypoglycemic activity of purified 1-Deoxynojirimycin has been rarely studied. It is also not known how FM and 1-Deoxynojirimycin affect the development of DM nephropathy. This study compared the antidiabetic effect of a commercial FM product with that of purified 1-Deoxynojirimycin in streptozotocin-induced diabetic rats. Seven days after induction, the diabetic rats were gavaged with FM (1, 3, 10, and 30 mg/kg/day),1-Deoxynojirimycin (30 mg/kg/day), or vehicle (distilled deionized water; 2 ml/kg/day) for 7 days. All doses of FM ameliorated fasting and post-prandial blood glucose concomitantly with an increase in peripheral and pancreatic levels of insulin and improved homeostasis model assessment (HOMA-IR) in diabetic rats in a dose-dependent manner. Increased thiobarbituric acid reactive substances (TBARS) and nitrate/nitrite levels in the kidney, liver, and muscle of diabetic rats were reversed by all doses of FM. The renal function of the diabetic rats was normalized by all doses of FM, while blood pressure changes were reversed by FM at doses of 3 mg/kg and above. Moreover, most of the above-mentioned parameters were improved by FM at doses of 3 mg/kg and above to a similar extent as that of 1-Deoxynojirimycin . The results showed superior antidiabetic potential of the commercial FM product for glycemic control and protection against the development of diabetic nephropathy.

Synthetic 1-deoxynojirimycin N-substituted peptides offer prolonged disruption to N-linked glycan processing.[Pubmed: 25352425]

A panel of 1-Deoxynojirimycin (DNJ) N-linked peptides were synthesized. Their IC50 values were measured in vitro against α-glucosidases I and II and were found to be in the micromolar range for both isozymes, and better than that of the iminosugar NB-DNJ (miglustat, 3) against α-glucosidase II. Cell-based studies revealed that although the free iminosugar 3 is most effective at disrupting N-linked glycan processing for short-term incubations (one day), when the cell-based studies were extended to three days, the 1-Deoxynojirimycin N-linked tetrapeptide KDEL, which is an endoplasmic reticulum (ER)-retaining sequence, performed far better than 3. In low inhibitor washout studies, NB-DNJ inhibition was decreased to zero after 24 h, but DNJ-KDEL retained 13  % activity. This method offers a general approach for targeting drugs to the ER and prolonging their activity. Moreover, it is modular, so as new iminosugars of increased potency are discovered, they can be added to this template for targeting.


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