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1,6,7-Trihydroxyxanthone

1,6,7-Trihydroxyxanthone

Catalog No. BCN5124
Size Price Stock
20mg $298 In stock
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Quality Control of 1,6,7-Trihydroxyxanthone

Chemical structure

1,6,7-Trihydroxyxanthone

Biological Activity of 1,6,7-Trihydroxyxanthone

1. 1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells.

1,6,7-Trihydroxyxanthone Dilution Calculator

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Chemical Properties of 1,6,7-Trihydroxyxanthone

Cas No. 25577-04-2 SDF Download SDF
SMILES c1cc(c2c(c1)oc3cc(c(cc3c2=O)O)O)O
Standard InChIKey SIYGDHCRSSTGRT-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H8O5/c14-7-2-1-3-10-12(7)13(17)6-4-8(15)9(16)5-11(6)18-10/h1-5,14-16H
Type of Compound Xanthones Appearance Yellow powder
Formula C13H8O5 M.Wt 244.2
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,6,7-Trihydroxyxanthone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,6,7-Trihydroxyxanthone

This product is isolated and purified from the herbs of Garcinia cowa

References on 1,6,7-Trihydroxyxanthone

MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells.[Pubmed: 25416134]


In the present study, an active ingredient, 1,6,7-Trihydroxyxanthone (THA), derived from Goodyera oblongifolia was found to strongly suppress cell growth and induce apoptosis in liver cancer cells. MicroRNAs are a group of small non-coding RNAs that regulate gene expression at post-transcriptional levels. Our results demonstrated that miR-218 was up-regulated and oncogene Bmi-1 was down-regulated by 1,6,7-Trihydroxyxanthone treatment. Further investigation showed that 1,6,7-Trihydroxyxanthone-induced-miR-218 up-regulation could lead to activation of tumor suppressor P16(Ink4a) and P14(ARF), the main down-stream targets of Bmi-1. In conclusion, 1,6,7-Trihydroxyxanthone might be a potential anti-cancer drug candidate, at least in part, through the activation of miR-218 and suppression of Bmi-1 expression.

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