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1,2-Benzenediol

1,2-Benzenediol

Catalog No. BCN6103
Size Price Stock
100mg $70 In stock
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Quality Control of 1,2-Benzenediol

Chemical structure

1,2-Benzenediol

Biological Activity of 1,2-Benzenediol

1. 1,2-Benzenediol is used as 5% aq. soln. for photometric detn. of Nb, Os, Ta, Ti, W, complexing agent of some metals (e.g. Al, Ti) (anionic complexes associated with basic dyes).

1,2-Benzenediol Dilution Calculator

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1,2-Benzenediol Molarity Calculator

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Chemical Properties of 1,2-Benzenediol

Cas No. 120-80-9 SDF Download SDF
Chemical Name benzene-1,2-diol
SMILES c1ccc(c(c1)O)O
Standard InChIKey YCIMNLLNPGFGHC-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H
Type of Compound Phenols Appearance Cryst.
Formula C6H6O2 M.Wt 110.1
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,2-Benzenediol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 9.0827 mL 45.4133 mL 90.8265 mL 181.653 mL 227.0663 mL
5 mM 1.8165 mL 9.0827 mL 18.1653 mL 36.3306 mL 45.4133 mL
10 mM 0.9083 mL 4.5413 mL 9.0827 mL 18.1653 mL 22.7066 mL
50 mM 0.1817 mL 0.9083 mL 1.8165 mL 3.6331 mL 4.5413 mL
100 mM 0.0908 mL 0.4541 mL 0.9083 mL 1.8165 mL 2.2707 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,2-Benzenediol

This product is isolated and purified from the heartwoods of Pseudolarix amabilis.

References on 1,2-Benzenediol

Reaction Kinetics of Catechol (1,2-Benzenediol) and Guaiacol (2-Methoxyphenol) with Ozone.[Pubmed: 26053029]


The kinetic reactions of 1,2-Benzenediol (catechol) and 2-methoxyphenol (guaiacol) with ozone were studied in a simulation chamber (8 m(3)) under dark conditions. The values (in cm(3) molecule(-1) s(-1)) determined for 1,2-Benzenediol and guaiacol under dry conditions are (13.5 ± 1.1) × 10(-18) and (0.40 ± 0.31) × 10(-18), respectively.

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII).[Pubmed: 25373500]


A series of phenolic compounds, including guaiacol, 4-methylguaiacol, 4-propylguaiacol, eugenol, isoeugenol, vanillin, syringaldehyde, 1,2-Benzenediol, 3-methyl catechol, 4-methyl 1,2-Benzenediol and 3-methoxy catechol were investigated for their inhibition of all the catalytically active mammalian isozymes of the Zn(2+)-containing CA (EC 4.2.1.1). All the phenolic compounds effectively inhibited human carbonic anhydrase isoenzymes (hCA I, II, IX and XII), with Kis in the range of 2.20-515.98 μM. The various isozymes showed diverse inhibition profiles. Among the tested phenolic derivatives, compounds 4-methyl 1,2-Benzenediol and 3-methoxy 1,2-Benzenediol showed potent activity as inhibitors of the tumour-associated transmembrane isoforms (hCA IX and XII) in the submicromolar range, with high selectivity. The results obtained from this research may lead to the design of more effective carbonic anhydrase isoenzyme inhibitors (CAIs) based on such phenolic compound scaffolds.

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