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(R)-(+)-Bay K 8644

(R)-(+)-Bay K 8644

Catalog No. BCC7107
Size Price Stock
10mg $258.00 Ship Within 7 Days
50mg $1,087.00 Ship Within 7 Days
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Quality Control of (R)-(+)-Bay K 8644

Chemical structure

(R)-(+)-Bay K 8644

Biological Activity of (R)-(+)-Bay K 8644

L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 and (S)-(-)- enantiomer.

(R)-(+)-Bay K 8644 Dilution Calculator

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(R)-(+)-Bay K 8644 Molarity Calculator



Chemical Properties of (R)-(+)-Bay K 8644

Cas No. 98791-67-4 SDF Download SDF
Chemical Name (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Formula C16H15F3N2O4 M.Wt 356.3
Solubility Soluble to 100 mM in ethanol and to 100 mM in DMSO
Storage Store at +4°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (R)-(+)-Bay K 8644

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8066 mL 14.0331 mL 28.0662 mL 56.1325 mL 70.1656 mL
5 mM 0.5613 mL 2.8066 mL 5.6132 mL 11.2265 mL 14.0331 mL
10 mM 0.2807 mL 1.4033 mL 2.8066 mL 5.6132 mL 7.0166 mL
50 mM 0.0561 mL 0.2807 mL 0.5613 mL 1.1226 mL 1.4033 mL
100 mM 0.0281 mL 0.1403 mL 0.2807 mL 0.5613 mL 0.7017 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (R)-(+)-Bay K 8644

Effects of nifedipine and Bay K 8644 on the R-PIA and caffeine-induced changes in the locomotor activity of rats.[Pubmed: 8870030]

Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifedipine (5 mg kg-1) and the channel activator Bay K 8644 (0.5 mg kg-1) did not alter the locomotor activity. However, both drugs significantly potentiated the inhibitory effect of R-PIA on the locomotor activity. Additionally, caffeine induced increase in the locomotor activity was significantly blocked by nifedipine and Bay K 8644. This interaction might be due to the inhibitory effects of nifedipine and Bay K 8644 on the uptake of adenosine by rat brain.


(R)-(+)-Bay K 8644,98791-67-4,Membrane Transporter/Ion Channel,Calcium Channel, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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