Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 38

  1. Cat.No. Product Name Information/Activity
  2. BCC8041 Huwentoxin XVI Potent and reversible N-type Ca<sup>2+</sup> channel blocker Huwentoxin XVI chemical structure
  3. BCC3797 Isradipine (Dynacirc) Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM. Isradipine (Dynacirc) chemical structure
  4. BCC7561 L-651,582 Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects. L-651,582 chemical structure
  5. BCC5238 Lercanidipine hydrochloride Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class. Lercanidipine hydrochloride chemical structure
  6. BCC4380 Loperamide HCl Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist. Loperamide hydrochloride is a selective and competitive Loperamide HCl chemical structure
  7. BCC1749 Mibefradil dihydrochloride Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively. Mibefradil dihydrochloride chemical structure
  8. BCC4808 Nifedipine Nifedipine (BAY-a-1040) is a potent calcium channel blocker and drug of choice for cardiac insufficiencies. Nifedipine chemical structure
  9. BCC3799 Nilvadipine Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM. Nilvadipine chemical structure
  10. BCC3823 Nimodipine Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine chemical structure
  11. BCC4381 Nitrendipine Nitrendipine is a calcium channel blocker with marked vasodilator action. Nitrendipine chemical structure

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