Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 39

  1. Cat.No. Product Name Information/Activity
  2. BCC1803 NNC 55-0396 NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. NNC 55-0396 chemical structure
  3. BCC7706 PD 173212 PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. PD 173212 chemical structure
  4. BCC6255 ProTx I 484598-35-8 ProTx I chemical structure
  5. BCC5952 SNX 482 203460-30-4 SNX 482 chemical structure
  6. BCC7181 SR 33805 oxalate 121346-33-6 SR 33805 oxalate chemical structure
  7. BCC4747 Verapamil HCl Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel antagonist. Verapamil HCl chemical structure
  8. BCN2207 Ascorbic acid PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit. Ascorbic acid chemical structure
  9. BCN2175 Pregabalin 148553-50-8 Pregabalin chemical structure
  10. BCC7104 A 68930 hydrochloride Potent, selective D<sub>1</sub>-like agonist A 68930 hydrochloride chemical structure
  11. BCC7159 A 77636 hydrochloride Potent, selective D<sub>1</sub>-like agonist. Orally active A 77636 hydrochloride chemical structure

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