Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 34

  1. Cat.No. Product Name Information/Activity
  2. BCC4029 ICI 118,551 hydrochloride ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. ICI 118,551 hydrochloride chemical structure
  3. BCC6860 BRL 37344, sodium salt BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice. BRL 37344, sodium salt chemical structure
  4. BCC6949 CGP 12177 hydrochloride 64208-32-8 CGP 12177 hydrochloride chemical structure
  5. BCC7091 CL 316243 disodium salt 151126-84-0 CL 316243 disodium salt chemical structure
  6. BCC5688 ICI 215,001 hydrochloride 140850-02-8 ICI 215,001 hydrochloride chemical structure
  7. BCC7282 L-755,507 L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM. L-755,507 chemical structure
  8. BCC6881 Pindolol Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM). Pindolol chemical structure
  9. BCC7833 SR 58611A hydrochloride Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity. SR 58611A hydrochloride chemical structure
  10. BCC5878 ZD 2079 178600-17-4 ZD 2079 chemical structure
  11. BCC6852 ZD 7114 hydrochloride 129689-28-7 ZD 7114 hydrochloride chemical structure

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