Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 45

  1. Cat.No. Product Name Information/Activity
  2. BCC7617 L-838,417 286456-42-6 L-838,417 chemical structure
  3. BCC6170 MK 0343 MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic. MK 0343 chemical structure
  4. BCC6070 MRK 016 783331-24-8 MRK 016 chemical structure
  5. BCC6593 Muscimol Potent GABA<sub>A</sub> agonist Muscimol chemical structure
  6. BCC6564 TACA 38090-53-8 TACA chemical structure
  7. BCC7819 TCS 1205 355022-97-8 TCS 1205 chemical structure
  8. BCC6803 THIP hydrochloride Gaboxadol hydrochloride (Lu 02-030 hydrochloride; THIP hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). Gaboxadol hydrochloride is a non-opioid analgesic and has hypnotic activities. THIP hydrochloride chemical structure
  9. BCC6169 TP 003 628690-75-5 TP 003 chemical structure
  10. BCC6563 ZAPA sulfate 371962-01-5 ZAPA sulfate chemical structure
  11. BCC7387 (-)-Bicuculline methiodide 40709-69-1 (-)-Bicuculline methiodide chemical structure

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